[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P

Basic Information

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CAS Number

96736-12-8

Molecular Formula

C79H109N19O12

Molecular Weight

443.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)CC(C(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CNC5=CC=CC=C54)NC(=O)C(CCC(=O)N)NC(=O)C(CC6=CC=CC=C6)NC(=O)C7CCCN7C(=O)C(CCCCN)NC(=O)C8CCCN8C(=O)C(CCCN=C(N)N)N

InChI

InChI=1S/C79H109N19O12/c1-46(2)38-59(68(83)100)91-70(102)60(39-47(3)4)92-73(105)64(43-51-45-88-56-28-14-12-25-53(51)56)95-72(104)61(40-48-20-7-5-8-21-48)93-74(106)63(42-50-44-87-55-27-13-11-24-52(50)55)94-69(101)57(32-33-67(82)99)89-71(103)62(41-49-22-9-6-10-23-49)96-76(108)66-31-19-37-98(66)78(110)58(29-15-16-34-80)90-75(107)65-30-18-36-97(65)77(109)54(81)26-17-35-86-79(84)85/h5-14,20-25,27-28,44-47,54,57-66,87-88H,15-19,26,29-43,80-81H2,1-4H3,(H2,82,99)(H2,83,100)(H,89,103)(H,90,107)(H,91,102)(H,92,105)(H,93,106)(H,94,101)(H,95,104)(H,96,108)(H4,84,85,86)/t54-,57+,58+,59+,60+,61+,62-,63-,64-,65+,66+/m1/s1

InChIKey

XVOCEQLNJQGCQG-ACRSGXKRSA-N

LogP

1.8455000000000008

Topological Polar Surface Area

129.11 Å²

Hydrogen Bond Donor/Acceptor

6 / 8

Complexity

3110

Synonyms & References

English

L-Leucinamide,D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-
(D-Arg?00D-Phe?00D-Trp?·?00Leu??)-SubstanceP
(D-ARG1,D-PHE5,D-TRP7·9,LEU11)-SUBSTANCE P
[D-ARG1,D-PHE5,D-TRP7,9,LEU11]-SUBSTANCE P
L-Leucinamide,D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-p...
L-Leucinamide,D-arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leuc
(D-ARG1,D-PHE5,D-TRP7.9,LEU11)-SUBSTANCE P
AntagonistD,D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
D-Arg-L-Pro-L-Lys-L-Pro-D-Phe-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2
D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2
H-D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2
M.W. 1516.85 C79H109N19O12
D-Arginyl-L-prolyl-L-lysyl-L-prolyl-D-phenylalanyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide (ACI)
D
L
Substance P, 1-D-arginine-5-D-phenylalanine-7-D-tryptophan-9-D-tryptophan-11-L-leucinamide- (ZCI)
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P
L 756867
Modified substance P
Substance P analog
HY-103544
CS-0028072
AKOS024456872
96736-12-8
[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P
Antagonist D
BDBM50260268
[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P, >=95% (HPLC)
(D-Arg1,D-Phe5,D-Trp7?9,Leu11)-Substance P
RPKPFQWFWLL
MFCD00076802

MDL Number

MFCD00076802

FAQ

What is [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P (CAS: 96736-12-8)?

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P (CAS: 96736-12-8) is a synthetic peptide that mimics the structure and activity of the naturally occurring neuropeptide substance P. It consists of 11 amino acids and plays a significant role in pain transmission and neuroinflammation.

What are the main uses of [D-Arg1,D-Phe5,D-Trw7,9,Leu11]-substance P (CAS: 96736-12-8)?

[D-Arg1,D-Phe5,D-Trw7,9,Leu11]-substance P (CAS: 96736-12-8) is primarily used in research for its ability to mimic substance P's effects in studying pain mechanisms, inflammation, and neurodegenerative diseases. It is also utilized in developing pain management drugs and as a tool in pharmaceutical research.

Is [D-Arg1,D-Phe5,D-Trw7,9,Leu11]-substance P (CAS: 96736-12-8) safe?

[D-Arg1,D-Phe5,D-Trw7,9,Leu11]-substance P (CAS: 96736-12-8) is generally considered safe for research and pharmaceutical use when handled with appropriate safety precautions. However, it should be used in laboratories with proper ventilation and by trained personnel to minimize exposure risks.

How should [D-Arg1,D-Phe5,D-Trw7,9,Leu11]-substance P (CAS: 96736-12-8) be stored?

[D-Arg1,D-Phe5,D-Trw7,9,Leu11]-substance P (CAS: 96736-12-8) should be stored in a cool, dry place, protected from light and at a temperature not exceeding 25°C. It should be kept in a tightly sealed container to maintain its stability and integrity.