Ruxolitinib | CAS No. 941678-49-5

Ruxolitinib

Basic Information

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CAS Number

941678-49-5

Molecular Formula

C17H18N6

Molecular Weight

17.03 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Density

1.40

SMILES

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C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

InChI

InChI=1S/H3N/h1H3

InChIKey

QGZKDVFQNNGYKY-UHFFFAOYSA-N

LogP

0.16199999999999998

Topological Polar Surface Area

35.0 Å²

Hydrogen Bond Donor/Acceptor

3 / 1

Complexity

453

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(βR)-1H-pyrazole-1-propanenitrile
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
(R)-Ruxolitinib
1H-PYRAZOLE-1-PROPANENITRILE, .BETA.-CYCLOPENTYL-4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-, (.BETA.R)-
INCB018424
Ruxolitinib
Ruxolitinib (INCB018424,INCB18424, NCB018424,NCB18424)
Ruxolitinib INCB018424Jakafi
Ruxolitinib(INCB018424)
Ruxolitinib-D4
((3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile)
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propionitrile
(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
INCB-018424
(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile
Ruxolitinib (INCB018424)
INCB 018424
INCB18424
INC424
82S8X8XX8H
INCB018424 (Ruxolitinib)
C17H18N6
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
R-Ruxolitinib
Ruxolitinib [USAN:INN]
INCB 18424
INC 424
(3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-
(3R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile (ACI)
(3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

MDL Number

MFCD12031592

FAQ

What is Ruxolitinib (CAS: 941678-49-5)?

Ruxolitinib is a Janus kinase (JAK) inhibitor with the chemical formula C21H22N4O2S. It is a white to off-white powder that is soluble in DMSO and dimethylformamide. Ruxolitinib is known for its ability to modulate immune responses and is widely used in the treatment of certain hematological malignancies and autoimmune diseases.

What are the main uses of Ruxolitinib (CAS: 941678-49-5)?

Ruxolitinib is primarily used in the treatment of myelofibrosis, polycythemia vera, and other blood disorders. It also finds applications in research for studying inflammatory and autoimmune conditions. Additionally, it is used in pharmaceutical formulations for its immunomodulatory properties and in clinical trials for various diseases.

Is Ruxolitinib (CAS: 941678-49-5) safe?

Ruxolitinib is generally considered safe when used as directed, but it may cause side effects such as infections, anemia, and thrombocytopenia. Proper handling and use under medical supervision are essential. Safety standards include adherence to guidelines for pharmaceutical use and appropriate storage conditions to maintain its efficacy and safety.

How should Ruxolitinib (CAS: 941678-49-5) be stored?

Ruxolitinib should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 25°C and in airtight containers to prevent moisture exposure. Proper storage ensures stability and maintains the compound's therapeutic effectiveness.