2-Bromo-6-fluoropyridine

Basic Information

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CAS Number

937379-49-2

Molecular Formula

C5H3BrFN

Molecular Weight

175.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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C1=CC(=NC(=C1)Br)F

InChI

InChI=1S/C5H3BrFN/c6-4-2-1-3-5(7)8-4/h1-3H

InChIKey

ZIDIKYIZXMYHAW-UHFFFAOYSA-N

LogP

1.9831999999999999

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

78.8

Synonyms & References

English

A859653
InChI=1/C5H3BrFN/c6-4-2-1-3-5(7)8-4/h1-3
2-Bromo-6-fluoropyridine, AldrichCPR
AC-24935
Platinum(1+), (2-bromo-5-fluoropyridine-N)(9-hydroxy-6-methylpyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(1H,6H)-dionato-N1,N12)(6-methyl-3-pyridinol-N1)-, (SP-4-2)-, hexafluorophosphate(1-)
SCHEMBL103057
DTXSID80932219
SY014349
PS-8591
AKOS005064102
AC-5413
B3667
FT-0648076
6-bromo-2-fluoropyridine
2-brom-6-fluorpyridin
BCP14733
MFCD03095258
CS-W003029
EN300-104427
144100-07-2
2-Bromo-6-fluoro-pyridine
FT-0659759
ZIDIKYIZXMYHAW-UHFFFAOYSA-N
Platinum(1+), (2-bromo-5-fluoropyridine-kappaN)(9-hydroxy-6-methylpyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(1H,6H)-dionato-kappaN1,kappaN12)(6-methyl-3-pyridinol-kappaN1)-, (SP-4-2)-, hexafluorophosphate(1-)
10019-16-6
pyridine, 2-bromo-6-fluoro-
AM20050815
AB13626
937379-49-2
A3119
2-bromo-6-fluoropyridine

MDL Number

MFCD03095258

FAQ

What are the physical and chemical properties of 2-Bromo-6-fluoropyridine (CAS: 937379-49-2)?

2-Bromo-6-fluoropyridine (CAS: 937379-49-2) is a crystalline solid with a molecular weight of approximately 213.03 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetonitrile. Chemically, it is less reactive compared to other halogenated pyridines, showing moderate electrophilic substitution reactivity. It is stable under normal conditions but may decompose at high temperatures or under strong reducing conditions.

How is 2-Bromo-6-fluoropyridine (CAS: 937379-49-2) typically synthesized?

2-Bromo-6-fluoropyridine is typically synthesized via a multistep process involving the bromination of 6-fluoropyridine using N-bromosuccinimide (NBS) in the presence of a radical initiator like dibenzoyl peroxide. The reaction is usually carried out in an aqueous-organic solvent mixture, yielding the desired product with good selectivity and moderate to high yield, depending on the reaction conditions.

What industries use 2-Bromo-6-fluoropyridine (CAS: 937379-49-2)?

2-Bromo-6-fluoropyridine (CAS: 937379-49-2) finds applications in pharmaceuticals, where it serves as a building block for the synthesis of various drug intermediates. It is also used in the development of novel sensors and semiconductors due to its unique electronic properties. Additionally, it may be utilized in the synthesis of polymers with specific functional groups.

What precautions should be taken when handling 2-Bromo-6-fluoropyridine (CAS: 937379-49-2)?

When handling 2-Bromo-6-fluoropyridine (CAS: 937379-49-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be carefully cleaned up using appropriate absorbents, and the area should be thoroughly decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed emergency response procedures and storage guidelines.