Tucatinib | CAS No. 937263-43-9

Tucatinib

Basic Information

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CAS Number

937263-43-9

Molecular Formula

C26H24N8O2

Molecular Weight

480.53 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.41±0.1 g/cm3 (20 ºC 760 Torr),

SMILES

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CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5

InChI

InChI=1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31)

InChIKey

SDEAXTCZPQIFQM-UHFFFAOYSA-N

LogP

5.093520000000003

Topological Polar Surface Area

110.85000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 10

Complexity

796

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine
ARRY-380
Irbinitinib
Irbinitinib (ARRY-380)
N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolined...
ONT-380
ARRY 380
ONT 380
Tucatinib
6-DIAMINE
234248D0HH
Tucatinib [USAN:INN]
Tucatinib (USAN/INN)
N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine
GTPL9922
SDEAXTCZPQIFQM-UHFFF
N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine (ACI)
Tukysa
N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine
N6-(4,5-dihydro-4,4-dmethyl-2-oxazolyl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-A)pyridin-7-Yloxy)phenyl)-4,6-quinazolinediamine
tucatinibum
TUCATINIB [WHO-DD]
AKOS026750449
NS00072928
Tucatinib [INN]
TUCATINIB [ORANGE BOOK]
ARRY-380; 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-; N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine;
Arry 380
Tucatinib (Irbinitinib,ARRY-380)?
DTXSID601027958
Q25100690

MDL Number

MFCD22380467

FAQ

What regulatory guidelines apply to tucatinib (CAS: 937263-43-9)?

Tucatinib (CAS: 937263-43-9) is regulated under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), and falls under the purview of the European Union’s Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation. Additionally, FDA and EPA have specific requirements for its handling, storage, and disposal, ensuring safety and environmental protection.

Are there alternatives to tucatinib (CAS: 937263-43-9) in synthesis?

Alternatives to tucatinib (CAS: 937263-43-9) in synthesis include similar drug candidates with similar mechanisms of action, such as pertuzumab and trastuzumab, which are often used as alternatives. Common substitutes in the synthesis process include alternative reagents like oxalyl chloride or thionyl chloride, depending on the specific synthetic route.

What is the market or research trend for tucatinib (CAS: 937263-43-9)?

The market for tucatinib (CAS: 937263-43-9) is growing, driven by increasing research interest in HER2-positive breast cancer treatments. Market trends show a focus on personalized medicine and combination therapies. Research is also exploring the potential of tucatinib in combination with other drugs to improve efficacy and expand its application in oncology.

How should waste containing tucatinib (CAS: 937263-43-9) be handled?

Waste containing tucatinib (CAS: 937263-43-9) should be collected in appropriate containers, labeled with the chemical name and CAS number. Incineration or professional waste disposal services should be used for disposal. Environmental protection precautions include ensuring no spillage or leaks occur, and following local and national environmental regulations to prevent contamination of soil and water sources.