2-Chloro-4-fluorobenzyl chloride

Basic Information

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CAS Number

93286-22-7

Molecular Formula

C7H5Cl2F

Molecular Weight

179.02 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

194°C (rough estimate)

Density

1.37

Refractive Index

1.534

SMILES

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C1=CC(=C(C=C1F)Cl)CCl

InChI

InChI=1S/C7H5Cl2F/c8-4-5-1-2-6(10)3-7(5)9/h1-3H,4H2

InChIKey

HMIAXVWVTBIGON-UHFFFAOYSA-N

LogP

3.2179

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

108

Safety Information

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Hazard Statement

H227 Combustible liquid
Flammable liquids

H290 May be corrosive to metals
Corrosive to Metals

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Lachrymatory

Synonyms & References

English

2-Chloro-1-(chloromethyl)-4-fluorobenzene
2-Chloro-4-fluorobenzyl chloride
2-Chloro-4-fluorobenzylchloride
2-Chloro-4-Fluorochlorobenzyl
ALPHA,2-DICHLORO-4-FLUOROTOLUENE
BENZENE, 2-CHLORO-1-(CHLOROMETHYL)-4-FLUORO-
2-chloro-1-(chloromethyl)-4-fluoro-benzene
KSC493Q6N
PARAGOS 500065
HMIAXVWVTBIGON-UHFFFAOYSA-N
WT1805
STL197884
SBB005760
LABOTEST-BB
2-Chloro-1-(chloromethyl)-4-fluorobenzene (ACI)
2-chloro-1-(chloromethyl)-4-fluorobenzene
MFCD00236026
DTXSID70369353
PS-10670
C1998
CS-0179770
2-Chloro-4-fluorobenzyl chloride, AldrichCPR
93286-22-7
EN300-18254
DB-024286
SCHEMBL531667
AKOS000400729

MDL Number

MFCD00236026

FAQ

What are the physical and chemical properties of 2-Chloro-4-fluorobenzyl chloride (CAS: 93286-22-7)?

2-Chloro-4-fluorobenzyl chloride is a white crystalline solid with a molecular weight of approximately 196.04 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. The compound is highly reactive due to the presence of the electrophilic chlorine and fluoro substituents, making it prone to nucleophilic substitution reactions.

How is 2-Chloro-4-fluorobenzyl chloride (CAS: 93286-22-7) typically synthesized?

2-Chloro-4-fluorobenzyl chloride can be synthesized through a series of reactions involving the chlorination of 4-fluorobenzyl alcohol using thionyl chloride. This process involves the addition of thionyl chloride to the alcohol in the presence of a suitable catalyst to facilitate the electrophilic substitution reaction.

What industries use 2-Chloro-4-fluorobenzyl chloride (CAS: 93286-22-7)?

2-Chloro-4-fluorobenzyl chloride is primarily used in the pharmaceutical and organic synthesis industries. It serves as a key intermediate in the synthesis of various drugs and chemical compounds, particularly those requiring specific functional groups for further derivatization. It is also utilized in the development of sensors and electronic materials.

What precautions should be taken when handling 2-Chloro-4-fluorobenzyl chloride (CAS: 93286-22-7)?

Handling 2-Chloro-4-fluorobenzyl chloride requires strict safety measures. It should be conducted in a well-ventilated area or within a fume hood due to its respiratory hazard potential. Personal protective equipment (PPE) including gloves, safety goggles, and laboratory coat should be worn. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.