Imipenem-Cilastatin sodium hydrate

Basic Information

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CAS Number

92309-29-0

Molecular Formula

C28H43N5O9S2

Molecular Weight

657.8 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.CC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)O)C

InChI

InChI=1S/C16H26N2O5S.C12H17N3O4S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/b12-6-;/t10-,11+;6-,7-,9-/m11/s1

InChIKey

NCCJWSXETVVUHK-ZYSAIPPVSA-N

LogP

1.37730

Complexity

1010

Synonyms & References

English

Tainem
CHEMBL1628401
Thienam
imipenem - cilastatin
Cilastatin, Imipenem
cilastatin, imipenem drug combination
Imipenem-Cilastatin sodium hydrate
Imipenem and cilastatin
1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R-(5alpha,6alpha(R*)))-, mixt. with (R-(R*,S*-(Z)))-7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptanoic acid
1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-((1R)-1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R,6S)-, mixt. with (2Z)-7-(((2R)-2-amino-2-carboxyethyl)thio)-2-((((1S)-2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptenoic acid
Tienam 500
Cilastatin / Imipenem
(Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid;(5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
92309-29-0
Imipenem / cilastatin
Sodium (Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
(Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid,(5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicy
IMIPENEM-CILASTATIN SODIUM
Cilastatin
Imipenem
Imipenem-cilastatin
MK 0787-MK 0791 mixture
MK 787-MK 791 mixture

MDL Number

MFCD23102426

Customs Code

3003209000

FAQ

What is Imipenem-Cilastatin sodium hydrate (CAS: 92309-29-0)?

Imipenem-Cilastatin sodium hydrate is a combination antibiotic that consists of imipenem, a broad-spectrum carbapenem antibiotic, and cilastatin, which prevents the degradation of imipenem by renal dehydropeptidase. This compound is available as a hydrate, which enhances its stability and bioavailability.

What are the main uses of Imipenem-Cilastatin sodium hydrate (CAS: 92309-29-0)?

Imipenem-Cilastatin sodium hydrate is primarily used in treating serious infections caused by a wide range of Gram-positive and Gram-negative bacteria. It is particularly useful in cases of multi-drug resistant infections and is administered intravenously or intramuscularly as a prescription medication.

Is Imipenem-Cilastatin sodium hydrate (CAS: 92309-29-0) safe?

Imipenem-Cilastatin sodium hydrate is generally considered safe when used appropriately under medical supervision. However, it may cause side effects such as allergic reactions, gastrointestinal issues, and kidney damage. Patients should follow medical advice and avoid self-medication to ensure safety.

How should Imipenem-Cilastatin sodium hydrate (CAS: 92309-29-0) be stored?

Imipenem-Cilastatin sodium hydrate should be stored at a temperature below 25°C (77°F) and protected from direct light. It should be kept in a tightly closed container to prevent moisture absorption. Additionally, it should be stored out of reach of children and pets to ensure safe handling and usage.