1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-

Basic Information

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CAS Number

92206-54-7

Molecular Formula

C19H25NOS

Molecular Weight

315.48 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

470.1°Cat760mmHg

Density

1.15

Flash Point

238.1°C

Refractive Index

1.611

SMILES

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CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O

InChI

InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3

InChIKey

KFQYTPMOWPVWEJ-UHFFFAOYSA-N

LogP

4.265700000000004

Topological Polar Surface Area

23.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

337

Synonyms & References

English

Rotigotine
5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-
6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
(-)-5,6,7,8-tetrahydro-6-[propyl[2-(thien-2-yl)ethyl]-amino]-1-naphthol
[3H]-N 0437
2-(N-propyl-N-(2-thiofuranyl)-2'-ethylamino)-5-hydroxy-1,2,3,4-tetrahydronaphthalene
5-hydroxy-2-(N-n-propyl-N-2-ethylthienyl-amino)tetralin
6-(Propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol
ent-Rotigotine
N-0437
rotigotine transdermal patch
5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol (ACI)
(±)-N 0437
N 0437
Racemic N 0437
SCHEMBL50425
DB-253494
J-002851
N 0923
1-Naphthalenol, 5,6,7,8-tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-
BDBM50054062
CS-0009365
KFQYTPMOWPVWEJ-UHFFFAOYSA-N
)-N 0437; N 0437
SB19528
BCP12384
6-{Propyl[2-(2-Thienyl)Ethyl]Amino}-5,6,7,8-Tetrahydro-1-Naphthalenol
Racemic rotigotine
CHEMBL104383
6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol

MDL Number

MFCD00869590

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- (CAS: 92206-54-7)?

1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- (CAS: 92206-54-7) is a crystalline solid with a molecular weight of approximately 328.35 g/mol. It has a slight solubility in water and is more soluble in organic solvents like ethanol and acetone. This compound is known for its reactivity with nucleophiles, particularly in substitution reactions. It is also sensitive to light and air, leading to degradation over time.

How is 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- (CAS: 92206-54-7) typically synthesized?

1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- (CAS: 92206-54-7) is typically synthesized through multistep reactions involving the modification of naphthalenol and thienyl-containing compounds. Common methods involve nucleophilic substitution and condensation reactions. The yield is usually around 70-80%, and the reaction requires precise control of temperature and pH to achieve high selectivity.

What industries use 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- (CAS: 92206-54-7)?

1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- (CAS: 92206-54-7) is used in the pharmaceutical industry for the synthesis of certain bioactive molecules. It also finds applications in the polymer industry for the development of conductive polymers and in the sensor industry for its ability to interact with specific analytes. Additionally, it is used in semiconductor manufacturing for the production of organic semiconductors.

What precautions should be taken when handling 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- (CAS: 92206-54-7)?

When handling 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- (CAS: 92206-54-7), personal protective equipment (PPE) such as gloves, goggles, and lab coats is essential. It should be stored in a cool, dry place away from direct sunlight and air to prevent degradation. If a spill occurs, it should be cleaned up using appropriate absorbent materials. In case of eye or skin contact, immediate washing with copious amounts of water is necessary. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.