Dactolisib | CAS No. 915019-65-7

Dactolisib

Basic Information

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CAS Number

915019-65-7

Molecular Formula

C30H23N5O

Molecular Weight

469.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

288-289°C

Boiling Point

701°C at 760 mmHg

Density

1.299

Flash Point

377.767°C

Refractive Index

1.705

SMILES

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CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

InChI

InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3

InChIKey

JOGKUKXHTYWRGZ-UHFFFAOYSA-N

LogP

4.36208

Complexity

872

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
BEZ235
2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phe...
2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile
Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-a,a-dimethyl-
Bez235 (nvp-bez235)
BEZ235 (NVP-BEZ235, Dactolisib)
NVP-BEZ 235
NVP-BEZ235 (BEZ235)
2-methyl-2-[3-methyl-2-oxo-8-(3-quinolinyl)-1-imidazo[4,5-c]quinolinyl]propanenitrile
BEZ-235
Dactolisib
NVPBEZ235
BEZ 235
NVP BEZ235
RUJ6Z9Y0DT
JOGKUKXHTYWRGZ-UHFFFAOYSA-N
2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile
2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihyd
4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethylbenzeneacetonitrile (ACI)
2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile
2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-1H,2H,3H-imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile
BEZ 23
NVP-BEZ 235NX
NVPBE 235
RTB 101
2-Methyl-2-(4-{3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl}phenyl)propanenitrile
NSC 751249
BCP9000397
MFCD10565944

MDL Number

MFCD10565944

FAQ

What is Dactolisib (CAS: 915019-65-7)?

Dactolisib (CAS: 915019-65-7) is a phosphoinositide 3-kinase (PI3K) inhibitor used in the treatment of certain types of cancer and rare genetic disorders. It is a white to off-white crystalline powder with a molecular formula of C29H29N7O3 and a molecular weight of 525.59.

What are the main uses of Dactolisib (CAS: 915019-65-7)?

Dactolisib (CAS: 915019-65-7) is primarily used in the treatment of solid tumors, particularly those with a specific genetic mutation, and in the treatment of a rare genetic disorder called Birt-Hogg-Dubé syndrome. It is also used in clinical trials for other conditions.

Is Dactolisib (CAS: 915019-65-7) safe?

Dactolisib (CAS: 915019-65-7) is generally considered safe when used as prescribed under medical supervision. However, it can cause side effects such as nausea, diarrhea, and fatigue. Users should follow all safety guidelines and precautions provided by healthcare professionals to minimize risks.

How should Dactolisib (CAS: 915019-65-7) be stored?

Dactolisib (CAS: 915019-65-7) should be stored at room temperature (15°C to 30°C) and in a tightly closed container to protect it from moisture. It should be kept away from direct sunlight and stored in a dry place to ensure its stability and efficacy. Avoid freezing or overheating the compound as it may affect its quality and safety.