Dimethyl (1-diazo-2-oxopropyl)phosphonate

Basic Information

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CAS Number

90965-06-3

Molecular Formula

C5H9N2O4P

Molecular Weight

192.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Agricultural Chemicals Pesticides Insecticides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Liquid

Density

0.800-0.850 g/mL at 20 °C

Refractive Index

n20/D 1.352-1.354

SMILES

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CC(=O)C(=[N+]=[N-])P(=O)(OC)OC

InChI

1S/C5H9N2O4P/c1-4(8)5(7-6)12(9,10-2)11-3/h1-3H3

InChIKey

SQHSJJGGWYIFCD-UHFFFAOYSA-N

LogP

0.77066

Complexity

281

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 3 Class 3

Synonyms & References

English

Dimethyl (1-diazo-2-oxopropyl)phosphonate
Ohira-Bestmann Reagent
(1-DIAZO-2-OXO-PROPYL)-PHOSPHONIC ACID DIMETHYL ESTER
(Z)-1-diazonio-1-dimethoxyphosphorylprop-1-en-2-olate
Dimethyl (1-diazo-2-oxopropyl)-phosphonatephosphonate
Phosphonic acid, P-(1-diazo-2-oxopropyl)-, dimethyl ester
Bestmann-Ohira Reagent
Dimethyl (1-azoacetonyl)phosphonate solution
Dimethyl (acetyldiazomethyl)phosphonate solution
1-Diazoacetonylphosphonic Acid Dimethyl Ester
(1-Diazo-2-oxopropyl)phosphonic Acid Dimethyl Ester
Dimethyl 1-Diazoacetonylphosphonate
1-Diazoacetonylphosphonic Acid Dimethyl Ester (10% in Acetonitrile)
(1-Diazo-2-oxopropyl)phosphonic Acid Dimethyl Ester (10% in Acetonitrile)
Dimethyl 1-Diazoacetonylphosphonate (10% in Acetonitrile)
Ohira-Bestmann Reagent (10% in Acetonitrile)
Dimethyl P-(1-diazo-2-oxopropyl)phosphonate (ACI)
Phosphonic acid, (1-diazo-2-oxopropyl)-, dimethyl ester (9CI)
(1-Diazo-2-oxopropyl)phosphonic acid dimethyl ester
1-Diazo-1-(dimethyl phosphono)acetone
1-Diazo-1-dimethoxyphosphoryl-propan-2-one
Bestmann reagent
Bestmann-Ohira reagent
Dimethyl (1-azo-2-oxopropyl)phosphonate
Dimethyl (1-azoacetonyl)phosphonate
Dimethyl (acetyldiazomethyl)phosphonate
Ohira's reagent
Ohira-Bestmann phosphonate
Ohira-Bestmann reagent
α-Azido-α-(dimethyl phosphono)acetone
dimethyl (1-diazo-2-oxopropyl)-phosphonate

MDL Number

MFCD07368360

FAQ

What is Dimethyl (1-diazo-2-oxopropyl)phosphonate (CAS: 90965-06-3)?

Dimethyl (1-diazo-2-oxopropyl)phosphonate (CAS: 90965-06-3) is an organic phosphonate compound with the chemical formula C5H10N2O3P. It contains a diazo group (N2) and a ketone functionality (C=O) attached to a propyl chain, making it a versatile intermediate in chemical synthesis. The compound is typically a colorless liquid with a moderately high boiling point and is known for its reactivity in forming azido and amino derivatives.

What are the main uses of Dimethyl (1-diazo-2-oxopropyl)phosphonate (CAS: 90965-06-3)?

Dimethyl (1-diazo-2-oxopropyl)phosphonate (CAS: 90965-06-3) is widely used in pharmaceutical research as a precursor for synthesizing azido compounds and amino acids. It also serves in industrial applications for organic chemistry reactions and in the development of agrochemicals. Its utility in research stems from its ability to participate in nucleophilic substitutions and provide stable intermediates for complex molecule fabrication.

Is Dimethyl (1-diazo-2-oxopropyl)phosphonate (CAS: 90965-06-3) safe?

Dimethyl (1-diazo-2-oxopropyl)phosphonate (CAS: 90965-06-3) is a chemical intermediate and should be handled with appropriate safety measures. It may cause skin or eye irritation and is flammable. Safety data sheets (SDS) recommend using protective gloves, goggles, and ensuring proper ventilation. While not classified as highly toxic, it requires careful handling to avoid exposure and potential reactivity with incompatible materials.

How should Dimethyl (1-diazo-2-oxopropyl)phosphonate (CAS: 90965-06-3) be stored?

Dimethyl (1-diazo-2-oxopropyl)phosphonate (CAS: 90965-06-3) should be stored in a sealed, airtight container in a cool, dry place away from light. Maintain storage temperature between 2-8°C to ensure stability. Avoid exposure to moisture, heat, and incompatible substances like strong oxidizers. Proper labeling and storage in a well-ventilated area are essential to prevent degradation and ensure safety.