Crisaborole | CAS No. 906673-24-3

Crisaborole

Basic Information

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CAS Number

906673-24-3

Molecular Formula

C14H10BNO3

Molecular Weight

251.05 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O

InChI

InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2

InChIKey

USZAGAREISWJDP-UHFFFAOYSA-N

Complexity

361

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile
AN-2728
4-((1-Hydroxy-1,3-dihydrobenzo-[c][1,2]oxaborol-5-yl)oxy)benzonitrile
4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]Benzonitrile
5-(4-CYANOPHENOXY)-2,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE
AN 2728
Crisaborole
5-(4-Cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole
AN2728
Eucrisa
Crisaborole topical ointment 2%
Crisaborole (AN2728)
Q2R47HGR7P
AK102641
4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile
4-[(1-hydroxy-1,3-dihydr
4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-
4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile (ACI)
4-[(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile
Staquis
4-((1-HYDROXY-1,3-DIHYDROBENZO-[C][1,2]OXABOROL-5-YL)OXY)BENZONITRILE
DTXSID10238231
F51164
D11AH06
TQP0866
Crisaborole, >=98% (HPLC)
DB-078771
1073669-75-6
BCP08677
UNII-Q2R47HGR7P
4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzonitrile

MDL Number

MFCD17169940

FAQ

What is Crisaborole (CAS: 906673-24-3)?

Crisaborole is a synthetic compound with the chemical formula C16H18N2O3. It is a topical phosphodiesterase 4 (PDE4) inhibitor known for its anti-inflammatory properties. This compound is commonly used in dermatology for treating atopic dermatitis and is available as a cream.

What are the main uses of Crisaborole (CAS: 906673-24-3)?

Crisaborole is primarily used in pharmaceuticals as a treatment for atopic dermatitis, particularly in over-the-counter topical creams. It also finds applications in research for studying inflammatory responses and in the development of new therapeutic agents for skin conditions.

Is Crisaborole (CAS: 906673-24-3) safe?

Crisaborole is generally considered safe when used as directed, with minimal systemic absorption. It has low toxicity and is well-tolerated in most patients. However, proper handling and skin protection are recommended to avoid irritation, especially during application.

How should Crisaborole (CAS: 906673-24-3) be stored?

Crisaborole should be stored in a cool, dry place away from direct light. It is stable at room temperature (15-25°C) and should be kept in a sealed container to prevent moisture exposure. Avoid storing near incompatible substances to maintain product integrity.