Bucelipase alfa

Basic Information

View in Editor

CAS Number

9026-00-0

Molecular Formula

C47H53NO15

Molecular Weight

871.93 g/mol

Basic Physical Properties

Solubility

Dissolve 1mg/ml in 0.1M phosphate buffer, pH 6.0 to 7.0

SMILES

View in Editor

[HH].[HH].[HH].[HH].[HH].[HH].[HH]

InChI

InChI=1S/C47H53NO15/c1-24-31(61-43(57)36(53)35(27-13-9-7-10-14-27)48-41(55)28-17-19-30(51)20-18-28)22-47(58)40(62-42(56)29-15-11-8-12-16-29)38-45(6,32(52)21-33-46(38,23-59-33)63-26(3)50)39(54)37(60-25(2)49)34(24)44(47,4)5/h7-20,31-33,35-40,51-54,58H,21-23H2,1-6H3,(H,48,55)

InChIKey

FGTVEMAKHGUDHO-UHFFFAOYSA-N

LogP

3.233100000000002

Topological Polar Surface Area

244.67999999999995 Å²

Hydrogen Bond Donor/Acceptor

6 / 16

Complexity

Synonyms & References

English

9074-06-0
824401-05-0
2197018-01-0
120962-03-0
65997-06-0
8007-01-0
CID 160315322
Luciferase from Vibrio fischeri (Photobacterium f)
9014-00-0
9026-00-0
Bucelipase alfa
Esterase, cholesterol
Cholesterol esterase
CHOLESTEROL ESTERASE FROM PSEUDOMONAS SP LYOPHILIZED POWDER
BEROL226SA
Cholesterol Esterase from hog pancreas
Sterol-ester acylhydrolase
Cholesterol Esterase from Pseudomonas fluorescens
Bile salt-stimulated lipase
Biocatalytics E3

MDL Number

MFCD00071052

FAQ

What is Bucelipase alfa (CAS: 9026-00-0)?

Bucelipase alfa (CAS: 9026-00-0) is an enzyme produced by recombinant DNA technology. It is primarily used in the treatment of lipase deficiency to aid in the digestion of fats and proteins. Bucelipase alfa is a glycoprotein with a molecular weight of approximately 30 kDa and consists of a single polypeptide chain with a carbohydrate moiety.

What are the main uses of Bucelipase alfa (CAS: 9026-00-0)?

Bucelipase alfa (CAS: 9026-00-0) is mainly used for the treatment of patients with lipase deficiency. It helps in the breakdown of dietary fats and proteins, thus improving the nutritional status of patients with this condition. It is also used in clinical trials for its potential therapeutic applications.

Is Bucelipase alfa (CAS: 9026-00-0) safe?

Bucelipase alfa (CAS: 9026-00-0) is generally safe when used as prescribed. However, it is important to follow the dosage instructions and monitor for any adverse reactions. Allergic reactions and gastrointestinal side effects are the most common, but severe allergic reactions require immediate medical attention.

How should Bucelipase alfa (CAS: 9026-00-0) be stored?

Bucelipase alfa (CAS: 9026-00-0) should be stored below 25°C to maintain its stability. It should be kept in a tightly sealed container and protected from light. Do not freeze the product as freezing may affect its efficacy. Proper storage conditions ensure its effectiveness for patient use.