Amino(5-methyl-2-thienyl)acetic acid

Basic Information

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CAS Number

89776-66-9

Molecular Formula

C7H9NO2S

Molecular Weight

171.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Density

1.347

SMILES

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CC1=CC=C(S1)C(C(=O)O)N

InChI

InChI=1S/C7H9NO2S/c1-4-2-3-5(11-4)6(8)7(9)10/h2-3,6H,8H2,1H3,(H,9,10)

InChIKey

HLZZCZZBTRRPPH-UHFFFAOYSA-N

LogP

1.14092

Topological Polar Surface Area

63.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

163

Synonyms & References

English

AMINO-(5-METHYL-THIOPHEN-2-YL)-ACETIC ACID
CS-0281147
WS-02043
Amino(5-methyl-2-thienyl)acetic acid #
89776-66-9
SY044856
2-amino-2-(5-methyl-2-thienyl)acetic acid
2-amino-2-(5-methylthiophen-2-yl)acetic acid
[5-Methyl-2-thienyl]glycine
A50309
alpha-Amino-5-methyl-2-thiopheneacetic acid
SCHEMBL11518982
AKOS010601509
2-(5-Methylthiophen-2-yl)glycine
FT-0759340
MFCD01211039
HLZZCZZBTRRPPH-UHFFFAOYSA-N
DTXSID60342357
EN300-1259854
2-Amino-2-(5-methylthiophen-2-yl)acetic acid
2-Thiopheneacetic acid,a-amino-5-methyl-
Amino-(5-methyl-thiophen-2-yl)-acetic acid
2-Thiopheneacetic acid,a-amino-5-methyl
5-Methyl-DL-2-thienylglycin
amino-(5-methyl-[2]thienyl)-acetic acid
Amino-(5-methyl-[2]thienyl)-essigsaeure

MDL Number

MFCD01211039

Customs Code

2934999090

FAQ

What are the physical and chemical properties of Amino(5-methyl-2-thienyl)acetic acid (CAS: 89776-66-9)?

Amino(5-methyl-2-thienyl)acetic acid is a white to off-white crystalline solid with a molecular weight of approximately 191.19 g/mol. It is slightly soluble in water and has good solubility in organic solvents. The compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions at the thiophene ring. It is stable under normal conditions but should be protected from strong acids and bases.

How is Amino(5-methyl-2-thienyl)acetic acid (CAS: 89776-66-9) typically synthesized?

Amino(5-methyl-2-thienyl)acetic acid can be synthesized through a multi-step process involving the preparation of the 5-methylthiophene derivative, followed by acylation with an acyl chloride or anhydride. The reaction is catalyzed by a Lewis acid and proceeds with good yield and selectivity. Commonly used catalysts include aluminum chloride or thionyl chloride. The final step involves the nucleophilic substitution of the chloride with ammonia to form the amino derivative.

What industries use Amino(5-methyl-2-thienyl)acetic acid (CAS: 89776-66-9)?

Amino(5-methyl-2-thienyl)acetic acid finds applications in the pharmaceutical industry for the synthesis of certain drugs, in polymer synthesis as a monomer, and in the development of sensors for detecting various analytes. It is also used in the semiconductor industry as a precursor for organic semiconductor materials.

What precautions should be taken when handling Amino(5-methyl-2-thienyl)acetic acid (CAS: 89776-66-9)?

When handling Amino(5-methyl-2-thienyl)acetic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The substance should be handled in a well-ventilated area, preferably under a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated until all residues are removed. The material safety data sheet (MSDS) should be consulted for detailed spill and disposal procedures. Storage should be in a cool, dry place away from strong acids and bases.