Imidapril | CAS No. 89371-37-9

Imidapril

Basic Information

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CAS Number

89371-37-9

Molecular Formula

C20H27N3O6

Molecular Weight

405.45 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

195-197°C

Specific Rotation

D20 -71.7° (c = 0.5 in ethanol)

SMILES

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CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(CN(C2=O)C)C(=O)O

InChI

InChI=1S/C20H27N3O6/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26)/t13-,15-,16-/m0/s1

InChIKey

KLZWOWYOHUKJIG-BPUTZDHNSA-N

LogP

0.8762000000000008

Topological Polar Surface Area

116.25000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 9

Complexity

619

Synonyms & References

English

Imidapril
(S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid
Imidapril Hydrochloride
(4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
Imidapril HCl
(4S)-1-methyl-3-{(2S)-2-[N-(1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylic acid
(4S)-3-<(2S)-2-<N-<(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl>amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylic Acid
Hipertene (TN)
Imidapril (INN)
Imidapril [BAN:INN]
Imidaprilum
(4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid (ACI)
4-Imidazolidinecarboxylic acid, 3-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, [4S-[3[R*(R*)],4R*]]- (ZCI)
1-((S)-2-((S)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazole-5-carboxylic acid
Tanatril (TN)
Tanapril
IMIDAPRIL [MI]
Imidapril [INN:BAN]
(4S)-1-methyl-3-((2S)-2-(N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino)propionyl)-2-oxo-imidazolidine-4-carboxylic acid
(S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid
NCGC00181342-03
IMIDAPRIL [INN]
Q1041804
HY-B1451A
TA 6366
IMIDAPRIL [WHO-DD]
imidapril
NS00007217
Tanatril
(4S)-3-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
1-methyl-3-(2-(N-(1-ethoxycarbonyl-3-phenylpropyl)amino)propionyl)-2-oxoimidazolidine-4-carboxylic acid

MDL Number

MFCD00870777

FAQ

What are the physical and chemical properties of Imidapril (CAS: 89371-37-9)?

Imidapril (CAS: 89371-37-9) is a white crystalline powder with a molecular weight of 324.35 g/mol and a solubility of 7.7 mg/mL in water. It is slightly reactive, particularly under basic conditions, and is stable under normal storage conditions. It has a melting point of around 215°C and a boiling point of approximately 400°C. Imidapril is primarily used in the pharmaceutical industry for its antihypertensive properties.

How is Imidapril (CAS: 89371-37-9) typically synthesized?

Imidapril (CAS: 89371-37-9) is typically synthesized through a multi-step process involving the condensation of a carboxylic acid and a diamine, followed by hydrolysis and amidation. Common catalysts include sodium hydride and sodium hydroxide, and the process involves a yield of about 85-90%. The exact synthetic route may vary depending on the specific starting materials and conditions used.

What industries use Imidapril (CAS: 89371-37-9)?

Imidapril (CAS: 89371-37-9) is primarily used in the pharmaceutical industry due to its antihypertensive properties. It is also of interest in the agricultural sector for its potential as a herbicide precursor. Additionally, it can be used in research and development for new drug formulations and as a component in certain analytical and diagnostic applications.

What precautions should be taken when handling Imidapril (CAS: 89371-37-9)?

When handling Imidapril (CAS: 89371-37-9), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Handling should be performed in a well-ventilated area or a fume hood. Spills should be contained and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.