Manidipine Hydrochloride

Basic Information

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CAS Number

89226-75-5

Molecular Formula

C35H38Cl2N4O6

Molecular Weight

683.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

228-235°C

Boiling Point

722 °C at 760 mmHg

Water Solubility

Soluble in DMSO. Slightly soluble in water and ethanol /n

Flash Point

722 °C at 760 mmHg

SMILES

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CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl

InChI

1S/C35H38N4O6.ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;/h4-16,23,32-33,36H,17-22H2,1-3H3;1H

InChIKey

UFIXGLLGFBWKAV-UHFFFAOYSA-N

LogP

6.48280

Complexity

1090

Safety Information

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Hazard Statement

Hazard Class

Class 6.1 Class 6.1

Toxicity

LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba)

Synonyms & References

English

MANIDIPINE DIHYDROCHLORIDE
Manidipine 2HCl
3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
CV-4093
Manidipine Dihydroch
MANIDIPINE HCL
manidipine hydrochloride
CV4093
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester Dihydrochloride
2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Dihydrochloride
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
Franidipine hydrochloride
Manidipine.2HCl
Manidipine (dihydrochloride)
(+-)-Manidipine hydrochloride
CV 4093
Calslot
DSSTox_CID_796
DSSTox_RID_75794
DSSTox_GSID_20796
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenyl
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)
(±)-Manidipine dihydrochloride
Manidipine dihydrochloride
3-(2-(4-benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
hydrochloride (1:2)
5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride
KS-1270
Manidipine hydrochloride [JAN]
MANIDIPINE HYDROCHLORIDE (MART.)
Manidipine hydrochloride (JP17)

MDL Number

MFCD00896434

Customs Code

2942000000

FAQ

What is Manidipine Hydrochloride (CAS: 89226-75-5)?

Manidipine Hydrochloride (CAS: 89226-75-5) is a calcium channel blocker used primarily in the treatment of hypertension. It has the chemical formula C17H21ClN2O4 and is known for its ability to relax blood vessels, improving blood flow and reducing blood pressure. It is white to off-white in appearance and is commonly available as a solid powder for pharmaceutical use.

What are the main uses of Manidipine Hydrochloride (CAS: 89226-75-5)?

Manidipine Hydrochloride (CAS: 89226-75-5) is mainly used as an antihypertensive drug to manage high blood pressure. It is also employed in research for studying cardiovascular effects and in the pharmaceutical industry for drug development. Its applications include treating hypertension and related cardiovascular conditions, making it a key compound in medical and scientific contexts.

Is Manidipine Hydrochloride (CAS: 89226-75-5) safe?

Manidipine Hydrochloride (CAS: 89226-75-5) is generally considered safe when used as directed in medical settings. However, it should be handled with care, following standard safety protocols to avoid exposure. Proper protective measures, such as gloves and safety goggles, are recommended during handling. It is important to adhere to safety standards for storage and use to ensure its effectiveness and minimize risks.

How should Manidipine Hydrochloride (CAS: 89226-75-5) be stored?

Manidipine Hydrochloride (CAS: 89226-75-5) should be stored in a cool, dry place away from moisture and light. It is typically kept in a sealed container at a temperature range of 15°C to 25°C. Proper storage conditions help maintain its chemical stability and prolong shelf life, ensuring it remains effective for pharmaceutical and research applications.