5-Chloro-2-fluoro-3-iodopyridine

Basic Information

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CAS Number

884495-31-2

Molecular Formula

C5H2ClFIN

Molecular Weight

257.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=C(C=NC(=C1I)F)Cl

InChI

InChI=1S/C5H2ClFIN/c6-3-1-4(8)5(7)9-2-3/h1-2H

InChIKey

ASCAFZNEDOLLTH-UHFFFAOYSA-N

LogP

2.4787

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

103

Synonyms & References

English

5-Chloro-2-fluoro-3-iodopyridine
5-Chloro-2-fluoro-3-iodo-pyridine
5-Chloro-2-fluoro-3-iodopyridine (ACI)
AKOS015891868
MFCD08277269
SCHEMBL16648011
DB-358846
EN300-748760
884495-31-2
FD10647
DTXSID30660550
GS-5028

MDL Number

MFCD08277269

FAQ

What are the physical and chemical properties of 5-Chloro-2-fluoro-3-iodopyridine (CAS: 884495-31-2)?

5-Chloro-2-fluoro-3-iodopyridine (CAS: 884495-31-2) is a crystalline solid with a molecular weight of approximately 328.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is highly reactive and exhibits significant reactivity towards nucleophiles and electrophiles. It is often used in organic synthesis due to its versatile functional groups.

How is 5-Chloro-2-fluoro-3-iodopyridine (CAS: 884495-31-2) typically synthesized?

5-Chloro-2-fluoro-3-iodopyridine (CAS: 884495-31-2) can be synthesized through a multi-step process involving halogenation and alkylation reactions. Commonly, pyridine undergoes chlorination and fluorination to form 5-chloro-2-fluoropyridine, which is then iodinated. This process typically requires the use of Lewis acids and may involve the use of pyridine itself as a solvent. The reaction conditions are carefully controlled to ensure high selectivity and yield.

What industries use 5-Chloro-2-fluoro-3-iodopyridine (CAS: 884495-31-2)?

5-Chloro-2-fluoro-3-iodopyridine (CAS: 884495-31-2) is primarily used in the pharmaceutical and fine chemical industries. It serves as a key intermediate in the synthesis of complex organic molecules and has potential applications in the development of new drugs and materials. Due to its unique functional groups, it can also be utilized in the preparation of materials for sensors and semiconductors.

What precautions should be taken when handling 5-Chloro-2-fluoro-3-iodopyridine (CAS: 884495-31-2)?

When handling 5-Chloro-2-fluoro-3-iodopyridine (CAS: 884495-31-2), it is crucial to use personal protective equipment (PPE) including gloves, goggles, and lab coats. The compound should be stored in a cool, dry place away from direct sunlight and should be handled in a fume hood to avoid inhalation of fumes. In case of a spill, it is important to follow the safety data sheet (SDS) guidelines, which may include the use of absorbent materials and proper disposal methods. Always ensure proper ventilation and follow all laboratory safety protocols.