Aloxistatin | CAS No. 88321-09-9

Aloxistatin

Basic Information

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CAS Number

88321-09-9

Molecular Formula

C17H30N2O5

Molecular Weight

342.44 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

126°C

Boiling Point

538°C at 760 mmHg

Density

1.0657 (rough estimate)

Solubility

Soluble in DMSO, DMF or ethanol

Refractive Index

1.5800 (estimate)

SMILES

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CCOC(=O)C1C(O1)C(=O)NC(CC(C)C)C(=O)NCCC(C)C

InChI

InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

InChIKey

SRVFFFJZQVENJC-IHRRRGAJSA-N

LogP

1.0101000000000002

Topological Polar Surface Area

97.03 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Complexity

450

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)-
E-64d [for Biochemical Research]
E-64d
(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]-butyl]amino]carbonyl]-2-oxiranecarboxylic acid ethyl ester
2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbo...
ALLATOSTATIN I
Aloxistatin
E 64d
E-64-d
E-64d (EST,EP 453,NSC 694281, Aloxistatin)
EST
L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester
Aloxistatin (E-64d) EST Loxistatin
E64c ethyl ester
ep453
LOXASTATIN
LOXISTATIN
(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester
Ethyl (2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylate
(2S,3S)-3-[[(2S)-4-Methyl-1-[(3-methylbutyl)amino]-1-oxo-2-pentanyl]carbamoyl]-2-oxiranecarboxylic Acid Ethyl Ester
Aloxistatine
Aloxistatinum
Aloxistatina
Aloxistatin [INN]
E 64c ethyl ester
EST (pharmaceutical)
Aloxistatine [French]
Aloxistatinum [Latin]
Aloxistatina [Spanish]
C17H30N2O5
EP 453

MDL Number

MFCD00132883

FAQ

What are the physical and chemical properties of Aloxistatin (CAS: 88321-09-9)?

Aloxistatin (CAS: 88321-09-9) is a crystalline compound with a molecular weight of approximately 435. Aloxistatin has a low solubility in water but is more soluble in organic solvents like methanol and DMSO. It is moderately reactive with carboxylate and amide groups. The compound exhibits good stability under acidic and basic conditions.

How is Aloxistatin (CAS: 88321-09-9) typically synthesized?

Aloxistatin (CAS: 88321-09-9) is typically synthesized through solid-phase peptide synthesis (SPPS). The synthesis involves coupling amino acids using Fmoc chemistry, followed by deprotection and cleavage from the resin. The process yields Aloxistatin with high selectivity and good yield, usually greater than 80%.

What industries use Aloxistatin (CAS: 88321-09-9)?

Aloxistatin (CAS: 88321-09-9) is primarily used in the pharmaceutical industry for its anti-angiogenic properties. It is also explored in the polymer and sensor industries for its potential as a bioactive agent and as a model compound for peptide studies.

What precautions should be taken when handling Aloxistatin (CAS: 88321-09-9)?

When handling Aloxistatin (CAS: 88321-09-9), it is important to use proper personal protective equipment (PPE) such as gloves and lab coats. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.