Fmoc-Hyp-OH | CAS No. 88050-17-3

Fmoc-Hyp-OH

Basic Information

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CAS Number

88050-17-3

Molecular Formula

C20H19NO5

Molecular Weight

353.37 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

189-193 °C

Boiling Point

595.5℃ at 760 mmHg

Density

1.407

Flash Point

314°C

Refractive Index

1.658

SMILES

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O=C(O)[C@H]1N(C(OCC2C3=CC=CC=C3C4=CC=CC=C24)=O)C[C@H](O)C1

InChI

InChI=1S/C20H19NO5/c22-12-9-18(19(23)24)21(10-12)20(25)26-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17-18,22H,9-11H2,(H,23,24)/t12-,18+/m1/s1

InChIKey

GOUUPUICWUFXPM-XIKOKIGWSA-N

LogP

2.4553000000000003

Topological Polar Surface Area

87.07000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

530

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

N-Fmoc-trans-4-hydroxy-L-proline
Fmoc-Hyp-OH
Fmoc-L-4-hydroxyproline
trans-N-Fmoc-4-hydroxy-L-proline
(2S,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
(2S,4R)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
Fmoc-(2S,4R)-(-)-4-hydroxypyrrolidine-2-carboxylic acid
Fmoc-L-Hydroxyproline
Fmoc-L-Hyp-OH
Fmoc-O-Hyp-OH
trans-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
FMoc-trans-4-hydroxy-L-proline
Fmoc-Hyp
Fmoc-trans-Hyp-OH
PubChem10495
KSC496S2P
N-alpha-(9-Fluorenylmethyloxycarbonyl)-trans-L-hydroxyproline
GOUUPUICWUFXPM-XIKOKIGWSA-N
Fmoc-trans-4-hydroxy-(L)-proline
RARECHEM EM WB 0137
N-FMOC-TRANS-4-HYDROXY-L-PROLINE
N-FMOC-L-TRANS-4-HYDROXYPROLINE
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-TRANS-L-HYDROXYPROLINE
N-ALPHA-FMOC-L-TRANS-4-HYDROXYPROLINE
trans-N-Fmoc-L-4-hydroxyproline
trans-1-(((9H-Fluoren-9-yl)Methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
FMoc-Hyp
(2S,4R)-1-(9H-Fluoren-9-ylmethoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
(2S,4R)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-4-hydroxypyrrolidine-2-carboxylic acid
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(9H-fluoren-9-ylmethyl) ester, (2S-trans)- (ZCI)
231: PN: US20070042401 PAGE: 33 claimed protein

MDL Number

MFCD00151929

Customs Code

2933990090

FAQ

What is Fmoc-Hyp-OH (CAS: 88050-17-3)?

Fmoc-Hyp-OH, also known as 2-(2-Amino-2-hydroxyethyl)-9-fluorenylmethanol, is a chemical compound used as a protecting group in solid-phase peptide synthesis. It has the molecular formula C20H20N2O4 and a molecular weight of 348.39 g/mol.

What are the main uses of Fmoc-Hyp-OH (CAS: 88050-17-3)?

Fmoc-Hyp-OH is primarily used in the chemical synthesis of peptides and proteins, particularly in solid-phase peptide synthesis. It serves as a protecting group for the hydroxyl group of tyrosine residues during peptide coupling reactions.

Is Fmoc-Hyp-OH (CAS: 88050-17-3) safe?

Fmoc-Hyp-OH is generally considered safe for laboratory use when handled with appropriate precautions. However, it is important to follow safety guidelines, including wearing appropriate personal protective equipment (PPE) such as gloves and goggles, and ensuring proper ventilation during use.

How should Fmoc-Hyp-OH (CAS: 88050-17-3) be stored?

Fmoc-Hyp-OH should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly closed container to prevent moisture absorption and degradation. The ideal storage temperature is below 25°C (77°F) to ensure stability and safety of the compound.