N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide | CAS No. 875320-29-9

N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide

Basic Information

CAS Number

875320-29-9

Molecular Formula

C21H26N6O2

Molecular Weight

394.48 g/mol

AD

Basic Physical Properties

Density

1.35

ONC(=O)c1cnc(nc1)N1CCC(CC1)CNCc1cn(c2c1cccc2)C

InChI

InChI=1S/C21H26N6O2/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28)

InChIKey

PAWIYAYFNXQGAP-UHFFFAOYSA-N

LogP

2.093499999999999

Topological Polar Surface Area

95.31 Ų

Hydrogen Bond Donor/Acceptor

3 / 8

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral
H315 Causes skin irritation
Skin corrosion/irritation
H319 Causes serious eye irritation
Serious eye damage/eye irritation
H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

  • N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide
  • N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-carboxamide
  • Quisinostat
  • Quisinostat (JNJ-26481585)
  • N-Hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide (ACI)
  • JNJ 26481585

MDL Number

MFCD17010272

FAQ

What regulatory guidelines apply to N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide (CAS: 875320-29-9)?

N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide (CAS: 875320-29-9) is subject to various regulatory guidelines including GHS classification for hazardous chemicals, REACH regulations for the European market, and FDA/EPA requirements for pharmaceutical and environmental safety compliance. It is important to consult the latest regulatory documents and guidelines for specific details.

Are there alternatives to N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide (CAS: 875320-29-9) in synthesis?

Alternatives to N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide (CAS: 875320-29-9) in synthesis include analogs such as similar piperidine derivatives, indolyl derivatives, and pyrimidine analogs. Common alternative reagents may include other amine derivatives or different functional groups. It's essential to evaluate both the efficacy and regulatory compliance of these alternatives.

What is the market or research trend for N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide (CAS: 875320-29-9)?

The market for N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide (CAS: 875320-29-9) is growing due to its potential in pharmaceutical applications. Research trends are focused on its medicinal chemistry, pharmacological properties, and potential as a therapeutic agent. Market demand is expected to rise as more studies validate its utility.

How should waste containing N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide (CAS: 875320-29-9) be handled?

Waste containing N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)-1-piperidinyl]-5-pyrimidinecarboxamide (CAS: 875320-29-9) should be collected and disposed of in accordance with local and international regulations. Proper incineration methods or professional waste disposal services should be used. Environmental protection precautions, including proper containment and handling to prevent exposure, are essential to ensure safety and compliance with regulatory requirements.

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