6-Azaspiro[2.5]octane

Basic Information

View in Editor

CAS Number

872-64-0

Molecular Formula

C7H13N

Molecular Weight

111.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Sticky Oil to Semi-Solid

SMILES

View in Editor

C1CC11CCNCC1

InChI

InChI=1S/C7H13N/c1-2-7(1)3-5-8-6-4-7/h8H,1-6H2

InChIKey

GIBPTWPJEVCTGR-UHFFFAOYSA-N

LogP

1.15

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

86.6

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

6-azaspiro[2.5]octane
6-azaspiro[2.5]octane hydrochloride
6-Aza-spiro[2.5]octane hydrochloride
6-Aza-spiro[2.5]octane
3426AJ
SB39234
AM804453
AB0073904
BB 0261409

MDL Number

MFCD14581272

FAQ

What are the physical and chemical properties of 6-Azaspiro[2.5]octane (CAS: 872-64-0)?

6-Azaspiro[2.5]octane (CAS: 872-64-0) is a cyclic compound with a molecular weight of approximately 112.18 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. This compound is relatively stable but reacts with strong oxidizing agents. It is often used in pharmaceutical and polymer applications due to its unique structural properties.

How is 6-Azaspiro[2.5]octane (CAS: 872-64-0) typically synthesized?

6-Azaspiro[2.5]octane (CAS: 872-64-0) can be synthesized via a ring-closing process starting from 1-hexene and ammonia. This method involves the ring-closing metathesis reaction catalyzed by Grubbs' second-generation catalyst, leading to a high yield and good selectivity. The reaction is carried out under inert conditions to avoid decomposition.

What industries use 6-Azaspiro[2.5]octane (CAS: 872-64-0)?

6-Azaspiro[2.5]octane (CAS: 872-64-0) is primarily used in the pharmaceutical and polymer industries. In pharmaceuticals, it serves as a precursor for the synthesis of various biologically active molecules. In polymers, it is used to enhance material properties in certain applications such as coatings and adhesives.

What precautions should be taken when handling 6-Azaspiro[2.5]octane (CAS: 872-64-0)?

When handling 6-Azaspiro[2.5]octane (CAS: 872-64-0), it is essential to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be handled in a well-ventilated area or fume hood to avoid inhalation. In case of spill, the area should be immediately flushed with water and the spill cleaned up according to standard safety procedures. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.