(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide | CAS No. 863127-76-8

Q: How is (2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide (CAS: 863127-76-8) typically synthesized?

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide can be synthesized via a condensation reaction between 2-chloro-6-methylacetophenone and ethoxyacryloyl chloride in the presence of a base such as triethylamine. The reaction yield is typically around 75-85%, and the process involves a key step of selective acylation to form the desired product.

Q: What industries use (2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide (CAS: 863127-76-8)?

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide is primarily used in the pharmaceutical and polymer industries. It can serve as a precursor for the synthesis of active pharmaceutical ingredients (APIs) and also finds applications in the formulation of polymer additives for enhanced properties such as thermal stability and mechanical strength.

Q: What precautions should be taken when handling (2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide (CAS: 863127-76-8)?

When handling (2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide, it is important to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and safety instructions.

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide

Basic Information

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CAS Number

863127-76-8

Molecular Formula

C12H14ClNO2

Molecular Weight

239.7 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

386.5℃ at 760 mmHg

Density

1.197

SMILES

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CCO/C=C/C(=O)Nc1c(C)cccc1Cl

InChI

InChI=1S/C12H14ClNO2/c1-3-16-8-7-11(15)14-12-9(2)5-4-6-10(12)13/h4-8H,3H2,1-2H3,(H,14,15)/b8-7+

InChIKey

DBYFNZJHXGNAGW-BQYQJAHWSA-N

LogP

3.1371200000000012

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

255

Synonyms & References

English

(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide
(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxy-2-propenamide
2-Propenamide, N-(2-chloro-6-methylphenyl)-3-ethoxy-, (2E)-
DBYFNZJHXGNAGW-BQYQJAHWSA-N
BCP12441
3496AC
AX8236628
ST24035089
127C768
(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyl acrylamide
(E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide

MDL Number

MFCD13185963

FAQ

What are the physical and chemical properties of (2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide (CAS: 863127-76-8)?

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide is a colorless to white crystalline solid with a molecular weight of approximately 256.2 g/mol. It has a melting point of 68-70°C and a limited solubility in water (solubility <1 g/L). This compound is reactive towards nucleophiles and exhibits good stability under acidic and basic conditions. It is not flammable but can undergo photodegradation.

How is (2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide (CAS: 863127-76-8) typically synthesized?

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide can be synthesized via a condensation reaction between 2-chloro-6-methylacetophenone and ethoxyacryloyl chloride in the presence of a base such as triethylamine. The reaction yield is typically around 75-85%, and the process involves a key step of selective acylation to form the desired product.

What industries use (2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide (CAS: 863127-76-8)?

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide is primarily used in the pharmaceutical and polymer industries. It can serve as a precursor for the synthesis of active pharmaceutical ingredients (APIs) and also finds applications in the formulation of polymer additives for enhanced properties such as thermal stability and mechanical strength.

What precautions should be taken when handling (2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide (CAS: 863127-76-8)?

When handling (2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide, it is important to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and safety instructions.