1-(Phenylmethyl)piperazine

Basic Information

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CAS Number

860027-50-5

Molecular Formula

C11H16N2

Molecular Weight

176.26 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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C1CN(CCN1)CC2=CC=CC=C2

InChI

InChI=1S/C11H16N2/c1-2-4-11(5-3-1)10-13-8-6-12-7-9-13/h1-5,12H,6-10H2

InChIKey

IQXXEPZFOOTTBA-UHFFFAOYSA-N

LogP

1.0917999999999994

Topological Polar Surface Area

15.27 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Synonyms & References

English

1-BENZYLPIPERAZINE
N-BENZYL PIPERAZINE
1-(phenylmethyl)-piperazine
4-benzylpiperazine
1-(Phenylmethyl)piperazine
N-Phenylpiperazine

MDL Number

MFCD00005967

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 1-(Phenylmethyl)piperazine (CAS: 860027-50-5)?

1-(Phenylmethyl)piperazine is a white crystalline solid with a molecular weight of approximately 214.27 g/mol. It is sparingly soluble in water but highly soluble in organic solvents such as ethanol and dimethylformamide. Chemically, it is stable under normal conditions but can react with strong acids or bases to form derivatives. It is also known for its amphoteric nature, allowing it to act as both an acid and a base in certain reactions.

How is 1-(Phenylmethyl)piperazine (CAS: 860027-50-5) typically synthesized?

1-(Phenylmethyl)piperazine is typically synthesized through the condensation of piperazine with phenylmethyl chloride. This reaction is catalyzed by a strong base such as triethylamine and proceeds with good yield. The process involves careful control of temperature and reaction time to achieve the desired product purity.

What industries use 1-(Phenylmethyl)piperazine (CAS: 860027-50-5)?

1-(Phenylmethyl)piperazine finds applications in various industries, including pharmaceuticals, where it serves as a building block for drug synthesis. It is also used in the polymer industry for the production of certain polymers and plasticizers. Additionally, it plays a role in sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 1-(Phenylmethyl)piperazine (CAS: 860027-50-5)?

When handling 1-(Phenylmethyl)piperazine, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure to the vapors. Spills should be immediately cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.