Gefitinib-d | CAS No. 857091-32-8

Gefitinib-d

Basic Information

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CAS Number

857091-32-8

Molecular Formula

C22H16ClD8FN4O3

Molecular Weight

454.95 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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COc1cc2ncnc(c2cc1OCCCN1C([2H])([2H])C([2H])([2H])OC(C1([2H])[2H])([2H])[2H])Nc1ccc(c(c1)Cl)F

InChI

InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)/i6D2,7D2,9D2,10D2

InChIKey

XGALLCVXEZPNRQ-IHGLQNJRSA-N

LogP

4.2756000000000025

Topological Polar Surface Area

68.74000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Synonyms & References

English

[2H8]-Gefitinib
Gefitinib D8
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)propoxy]quinazolin-4-amine
Gefitinib-d8
Gefitinib-d

MDL Number

MFCD30748179

FAQ

What is Gefitinib-d (CAS: 857091-32-8)?

Gefitinib-d (CAS: 857091-32-8) is a quinazoline derivative with antineoplastic properties, primarily used in the treatment of non-small cell lung cancer. It inhibits epidermal growth factor receptor (EGFR) tyrosine kinase activity.

What are the main uses of Gefitinib-d (CAS: 857091-32-8)?

Gefitinib-d (CAS: 857091-32-8) is mainly used in the treatment of non-small cell lung cancer in patients who have failed first-line chemotherapy and have mutations in the epidermal growth factor receptor (EGFR). It is also used in clinical trials for other types of cancer.

Is Gefitinib-d (CAS: 857091-32-8) safe?

Gefitinib-d (CAS: 857091-32-8) is generally considered safe when used as prescribed. However, it can cause side effects such as skin rash, diarrhea, and liver toxicity. Patients should be monitored closely for adverse reactions and appropriate protective measures should be taken.

How should Gefitinib-d (CAS: 857091-32-8) be stored?

Gefitinib-d (CAS: 857091-32-8) should be stored in a tightly sealed container at room temperature (15-30°C), protected from light and moisture. It should be kept out of reach of children and away from incompatible materials.