Cediranib maleate

Basic Information

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CAS Number

857036-77-2

Molecular Formula

C29H31FN4O7

Molecular Weight

566.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5.C(=CC(=O)O)C(=O)O

InChI

InChI=1S/C25H27FN4O3.C4H4O4/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30;5-3(6)1-2-4(7)8/h6-7,12-15,29H,3-5,8-11H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

JRMGHBVACUJCRP-BTJKTKAUSA-N

LogP

4.9360200000000045

Topological Polar Surface Area

147.1 Å²

Hydrogen Bond Donor/Acceptor

3 / 11

Complexity

743

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

D08883
CEDIRANIB MALEATE [JAN]
F85248
s5242
4-((4-fluoro-2-methyl-1h-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline maleate
A903494
BCP16806
(Z)-but-2-enedioic acid;4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline
Cediranib maleat
SCHEMBL1218427
4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline maleate
CHEMBL2103798
Cediranib (maleate)
AZD2171 maleate;4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline maleate
68AYS9A614
857036-77-2 (maleate)
CCG-270078
AZD2171 MALEATE
4-((4-FLUORO-2-METHYL-1H-INDOL-5-YL)OXY)-6-METHOXY-7-(3-PYRROLIDIN-1-YLPROPOXY)QUINAZOLINE (2Z)-BUT-2-ENEDIOATE
CEDIRANIB MALEATE [MART.]
Cediranib maleate [USAN]
Quinazoline, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)-, (2Z)-2-butenedioate (1:1)
Q27264241
NSC732208
CS-4774
Cediranib maleate
857036-77-2
AZD-2171 maleate
MS-30256
HY-13049
Cediranib maleate (JAN/USAN)

MDL Number

MFCD27665457

FAQ

What regulatory guidelines apply to cediranib maleate (CAS: 857036-77-2)?

Cediranib maleate (CAS: 857036-77-2) is subject to various regulatory guidelines including REACH, GHS classification, and FDA/EPA requirements. Companies must ensure compliance with these regulations for manufacturing, distribution, and use.

Are there alternatives to cediranib maleate (CAS: 857036-77-2) in synthesis?

Alternatives to cediranib maleate include similar inhibitors such as sorafenib and sunitinib. These compounds are often used as substitutes in synthesis due to their similar pharmacological properties. Other reagents like tyrosine kinase inhibitors may also be considered.

What is the market or research trend for cediranib maleate (CAS: 857036-77-2)?

The market trend for cediranib maleate (CAS: 857036-77-2) reflects an ongoing interest in angiogenesis inhibitors for cancer treatment. Recent research focuses on its efficacy and potential combination therapies. Market trends suggest increasing demand for this compound in clinical trials and therapeutic applications.

How should waste containing cediranib maleate (CAS: 857036-77-2) be handled?

Waste containing cediranib maleate (CAS: 857036-77-2) should be collected in appropriate, labeled containers and disposed of through professional waste disposal services. Incineration or other environmentally safe methods should be employed to ensure the safe and effective disposal of the waste. Compliance with local environmental regulations is essential.