2-(1-Naphthyl)-5-phenyl-1,3-oxazole

Basic Information

View in Editor

CAS Number

846-63-9

Molecular Formula

C19H13NO

Molecular Weight

271.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

104.0 to 107.0 deg-C

Density

1.178±0.06 g/cm3 (20 ºC 760 Torr),

Solubility

Insuluble (4.1E-4 g/L) (25 ºC),

SMILES

View in Editor

C1(C2=C3C=CC=CC3=CC=C2)=NC=C(C4=CC=CC=C4)O1

InChI

InChI=1S/C19H13NO/c1-2-8-15(9-3-1)18-13-20-19(21-18)17-12-6-10-14-7-4-5-11-16(14)17/h1-13H

InChIKey

WWVFJJKBBZXWFV-UHFFFAOYSA-N

LogP

5.161800000000003

Topological Polar Surface Area

26.03 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

339

Synonyms & References

English

2-(1-naphthyl)-5-phenyloxazole
2-(1-Naphthyl)-5-phenyloxazole [for scintillation spectrometry]
2-(1-Naphthyl)-5-phenyl-1,3-oxazole
2-(1-NAPHTHYL)-5-PHENYLOXAZOLE FOR LIQUID SCINTILLATION SPECTROMETRY
2-naphthalen-1-yl-5-phenyl-1,3-oxazole
2,6-DICHLORO-4-HYDROXY-3-NITROPYRIDINE
2-naphthalen-1-yl-5-phenyl-oxazole
2-naphthyl-5-phenyl-1,3-oxazole
A-naphthyl-5-phenyloxazole
α-NPO
ANPO
2-(1-naphthalenyl)-5-phenyl-oxazol
alpha-npo
5-Phenyl-2-cc-naphthyl-oxazol
2-alpha-Naphthyl-5-phenyloxazole
NSC 24857
Oxazole, 2-(1-naphthalenyl)-5-phenyl-
2-(Naphthalen-1-yl)-5-phenyloxazole
Oxazole, 2-(1-naphthyl)-5-phenyl-
.alpha.-NPO
E08CN4XD65
2-.alpha.-Naphthyl-5-phenyloxazole
2-(1-Naphthyl)-5-phenyloxazole (NPO)
2-a-Naphthyl-5-phenyloxazole
2-(naphthalen-1-yl)-5-phenyl-1,3-oxazole
NSC248
2-(1-Naphthyl)-5-phenyloxazole

MDL Number

MFCD00019714

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2-(1-naphthyl)-5-phenyl-1,3-oxazole (CAS: 846-63-9)?

2-(1-Naphthyl)-5-phenyl-1,3-oxazole (CAS: 846-63-9) is a white or off-white crystalline solid with a molecular weight of approximately 272.28 g/mol. It has low water solubility and moderate solubility in organic solvents like ethanol and acetone. This compound exhibits good thermal stability, with a decomposition temperature above 200°C. It is a moderately reactive compound, showing reactivity towards basic conditions and reducing agents.

How is 2-(1-naphthyl)-5-phenyl-1,3-oxazole (CAS: 846-63-9) typically synthesized?

2-(1-Naphthyl)-5-phenyl-1,3-oxazole can be synthesized via condensation reactions such as the Knoevenagel condensation of 1-naphthylamine with phenyl isoxazole. This reaction typically requires an acidic catalyst like p-toluenesulfonic acid (p-TSA) and is performed at room temperature. The yield is usually around 70-80%, and the product can be purified by recrystallization from ethanol.

What industries use 2-(1-naphthyl)-5-phenyl-1,3-oxazole (CAS: 846-63-9)?

2-(1-Naphthyl)-5-phenyl-1,3-oxazole (CAS: 846-63-9) is used in various industries, particularly in pharmaceuticals for its potential as a drug candidate in anticancer and antimicrobial applications. It is also employed in the synthesis of fluorescent materials and in the production of organic semiconductors due to its unique optical and electronic properties.

What precautions should be taken when handling 2-(1-naphthyl)-5-phenyl-1,3-oxazole (CAS: 846-63-9)?

When handling 2-(1-naphthyl)-5-phenyl-1,3-oxazole (CAS: 846-63-9), appropriate personal protective equipment (PPE) such as gloves and goggles should be worn. It should be stored in a well-ventilated area and handled in a fume hood to minimize exposure. Spills should be handled with caution, using appropriate cleanup materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.