![N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure](https://static.chemtradehub.com/structs/101/1013920-15-4-a4c8.webp "N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure")
N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number:
1013920-15-4
Molecular Formula:
C23H26FN5O3
1-[4-(Difluoromethoxy)phenyl]-1-propanone | CAS No. 83022-58-6
1-[4-(Difluoromethoxy)phenyl]-1-propanone
Basic Information
CAS Number
83022-58-6
Molecular Formula
C10H10F2O2
Molecular Weight
200.18 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 1-[4-(difluoromethoxy)phenyl]propan-1-one
- 1-(4-(Difluoromethoxy)phenyl)propan-1-one
- 1-Propanone, 1-(4-(difluoromethoxy)phenyl)-
MDL Number
MFCD02725146
FAQ
What are the physical and chemical properties of 1-[4-(Difluoromethoxy)phenyl]-1-propanone (CAS: 83022-58-6)?
1-[4-(Difluoromethoxy)phenyl]-1-propanone (CAS: 83022-58-6) is a white crystalline solid with a molecular weight of approximately 228.2 g/mol. It has a high solubility in common organic solvents like dichloromethane and ethanol. This compound is reactive, particularly towards nucleophiles and can undergo electrophilic aromatic substitution reactions. It is used in organic synthesis as a precursor for various pharmaceuticals and materials.
How is 1-[4-(Difluoromethoxy)phenyl]-1-propanone (CAS: 83022-58-6) typically synthesized?
1-[4-(Difluoromethoxy)phenyl]-1-propanone (CAS: 83022-58-6) is typically synthesized via a Wittig reaction using 4-(difluoromethoxy)phenyltriphenylphosphonium bromide and methyl vinyl ketone. The process involves the formation of a ylide intermediate, followed by the nucleophilic attack on the ketone. The reaction can be catalyzed by a mild base, and yields of up to 90% can be achieved with proper control of reaction conditions.
What industries use 1-[4-(Difluoromethoxy)phenyl]-1-propanone (CAS: 83022-58-6)?
1-[4-(Difluoromethoxy)phenyl]-1-propanone (CAS: 83022-58-6) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It also finds applications in the polymer industry for the development of advanced materials. Additionally, this compound is utilized in the production of sensors and semiconductors due to its unique chemical properties and reactivity.
What precautions should be taken when handling 1-[4-(Difluoromethoxy)phenyl]-1-propanone (CAS: 83022-58-6)?
When handling 1-[4-(Difluoromethoxy)phenyl]-1-propanone (CAS: 83022-58-6), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Handling should be done in a well-ventilated area or a fume hood to minimize inhalation exposure. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.
Related Compounds
![7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure](https://static.chemtradehub.com/structs/101/1016505-59-1-4c54.webp "7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure")
7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS Number:
1016505-59-1
Molecular Formula:
C8H7N3O2
![2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure](https://static.chemtradehub.com/structs/104/1048919-15-8-ba81.webp "2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure")
2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid
CAS Number:
1048919-15-8
Molecular Formula:
C12H14FNO4
1,5,8-Trihydroxy-3-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number:
110187-11-6
Molecular Formula:
C19H18O6
![9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure](https://static.chemtradehub.com/structs/119/1198286-24-6-4781.webp "9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure")
9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride
CAS Number:
1198286-24-6
Molecular Formula:
C16H26Cl2N2
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