1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Basic Information

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CAS Number

81246-81-3

Molecular Formula

C36H44N2O8Si

Molecular Weight

660.84 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.24±0.1 g/cm3 (20 ºC 760 Torr),

Solubility

Insuluble (3.5E-5 g/L) (25 ºC),

SMILES

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O=C1NC(C=CN1[C@@H]2O[C@H](COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5)[C@@H](O[Si](C)(C(C)(C)C)C)[C@H]2O)=O

InChI

InChI=1S/C36H44N2O8Si/c1-35(2,3)47(6,7)46-32-29(45-33(31(32)40)38-22-21-30(39)37-34(38)41)23-44-36(24-11-9-8-10-12-24,25-13-17-27(42-4)18-14-25)26-15-19-28(43-5)20-16-26/h8-22,29,31-33,40H,23H2,1-7H3,(H,37,39,41)/t29-,31-,32-,33-/m1/s1

InChIKey

ZATGYRPVDYINRF-WXQJYUTRSA-N

LogP

5.211200000000006

Topological Polar Surface Area

121.24000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 10

Complexity

1070

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

5'-DMT-3'-TBDMS-rU
5'-O-(4,4'-DiMethoxytrityl)-3'-O-t-butyldiMethylsilyl uridine
1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[dimethyl(tert-butyl)silyl]uridine
1-[(2S,3S,4R,5S)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-h

MDL Number

MFCD00274106

FAQ

What regulatory guidelines apply to 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS: 81246-81-3)?

The compound 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS: 81246-81-3) falls under the jurisdiction of various regulatory guidelines, including GHS (Global Harmonized System of Classification and Labeling of Chemicals) for hazard communication. In Europe, it is subject to REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) regulations. In the United States, FDA and EPA guidelines also apply for its handling and use in pharmaceutical and industrial applications.

Are there alternatives to 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS: 81246-81-3) in synthesis?

There are alternative reagents and isomers that can be used in the synthesis of similar compounds. For instance, using different protecting groups or substituents can lead to structurally related molecules. Common alternatives include 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione and 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methyl-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione, which can serve as effective substitutes in certain synthetic contexts.

What is the market or research trend for 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS: 81246-81-3)?

The market trend for 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS: 81246-81-3) reflects a growing interest in its applications in pharmaceutical and biotechnological research. Recent research trends focus on its potential as a precursor in medicinal chemistry and as a component in drug development for treating various diseases. Market demand is expected to increase with the advancement of these research efforts.

How should waste containing 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS: 81246-81-3) be handled?

Waste containing 1-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS: 81246-81-3) must be handled with care to ensure environmental safety. Waste should be collected in appropriate containers and stored separately. For disposal, incineration or professional waste disposal services should be utilized. Environmental protection measures include proper labeling, use of personal protective equipment, and adherence to local regulations to prevent contamination of soil, water, and air.