![N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure](https://static.chemtradehub.com/structs/101/1013920-15-4-a4c8.webp "N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure")
N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number:
1013920-15-4
Molecular Formula:
C23H26FN5O3
(6alpha,11beta,16alpha,17alpha)-17-{[(Chloromethyl)sulfanyl]carbonyl}-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate | CAS No. 80486-69-7
(6alpha,11beta,16alpha,17alpha)-17-{[(Chloromethyl)sulfanyl]carbonyl}-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate
Basic Information
CAS Number
80486-69-7
Molecular Formula
C25H31ClF2O5S
Molecular Weight
517.03 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- UNII-633N8637G3
- ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID, 6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)-, S-(CHLOROMETHYL) ESTER, (6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-
- Cloticasone propionate [USAN]
- Q27263558
- Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(chloromethyl) ester, (6alpha,11beta,16alpha,17alpha)-
- S-(Chloromethyl) 6alpha,9-difluoro-11beta,17-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carbothioate, 17-propionate
- CCI 18773
- 80486-69-7
- Cloticasone propionate (USAN)
- [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-(chloromethylsulfanylcarbonyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
- SCHEMBL42706
- CHEMBL2106066
- CCI 18773; S-Chlorofluticasone propionate
- CLOTICASONE PROPIONATE
- CCI-18773
- 633N8637G3
- D03569
- Cloticasone Propionate
- 5-Chloromethyl 6a,9a-Difluoro-11-hydroxy-16a-methyl-3-oxo-17a-(propionyloxy)-androsta-1,4-diene-17-carbothioate
- 5-CHLOROMETHYL 6A,9A-DIFLUORO-11ß-HYDROXY-16A-METHYL-3-OXO-17A-(PROPIONYLOXY)-ANDROSTA-1,4-DIENE-17ß-CARBOTHIOATE
- CLOTIONE
- CLOTIONE PROPIONATE
- (6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-(((chloromethyl)thio)carbonyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
MDL Number
MFCD00866168
FAQ
What are the physical and chemical properties of (6alpha,11beta,16alpha,17alpha)-17-{[(Chloromethyl)sulfanyl]carbonyl}-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate (CAS: 80486-69-7)?
The compound (6alpha,11beta,16alpha,17alpha)-17-{[(Chloromethyl)sulfanyl]carbonyl}-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate, CAS 80486-69-7, is a white crystalline solid with a molecular weight of approximately 688.9 g/mol. It is slightly soluble in water and ethanol. The compound exhibits good stability towards hydrolysis in neutral and basic media but is reactive towards acid conditions. It exhibits a moderate reactivity towards nucleophiles, which can lead to various functional group transformations.
How is (6alpha,11beta,16alpha,17alpha)-17-{[(Chloromethyl)sulfanyl]carbonyl}-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate (CAS: 80486-69-7) typically synthesized?
This compound can be synthesized via a multi-step process involving the conversion of a steroid precursor to the desired 17-carbonyl derivative. Common methods include the use of chlorosulfonic acid for sulfenylation, followed by acylation with a propionylating agent under mild or moderate conditions. The process involves careful control of reaction conditions to achieve high selectivity and yield. Catalysts such as phase transfer catalysts and acid scavengers are often employed to enhance reaction efficiency and product purity.
What industries use (6alpha,11beta,16alpha,17alpha)-17-{[(Chloromethyl)sulfanyl]carbonyl}-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate (CAS: 80486-69-7)?
This compound is primarily used in the pharmaceutical industry for its potential as a pharmacologically active compound. It may also find applications in the synthesis of other bioactive molecules. While its specific uses are limited, it can be relevant in research and development for drug discovery and synthesis of related compounds. However, detailed applications in other industries like polymers or sensors are not currently documented.
What precautions should be taken when handling (6alpha,11beta,16alpha,17alpha)-17-{[(Chloromethyl)sulfanyl]carbonyl}-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate (CAS: 80486-69-7)?
When handling (6alpha,11beta,16alpha,17alpha)-17-{[(Chloromethyl)sulfanyl]carbonyl}-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propionate, CAS 80486-69-7, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be handled carefully, and the material safety data sheet (MSDS) or safety data sheet (SDS) should be consulted for specific handling instructions. Due to its reactivity towards acid conditions, it is crucial to avoid contact with acids during handling and storage.
Related Compounds
![7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure](https://static.chemtradehub.com/structs/101/1016505-59-1-4c54.webp "7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure")
7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS Number:
1016505-59-1
Molecular Formula:
C8H7N3O2
![2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure](https://static.chemtradehub.com/structs/104/1048919-15-8-ba81.webp "2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure")
2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid
CAS Number:
1048919-15-8
Molecular Formula:
C12H14FNO4
1,5,8-Trihydroxy-3-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number:
110187-11-6
Molecular Formula:
C19H18O6
![9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure](https://static.chemtradehub.com/structs/119/1198286-24-6-4781.webp "9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure")
9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride
CAS Number:
1198286-24-6
Molecular Formula:
C16H26Cl2N2
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