2-Methylpyrazolo[1,5-a]pyrimidine

Basic Information

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CAS Number

78562-32-0

Molecular Formula

C7H7N3

Molecular Weight

133.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CC1=NN2C=CC=NC2=C1

InChI

InChI=1S/C7H7N3/c1-6-5-7-8-3-2-4-10(7)9-6/h2-5H,1H3

InChIKey

SMQAQNWCDKDKKO-UHFFFAOYSA-N

LogP

1.0377199999999998

Topological Polar Surface Area

30.19 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

126

Synonyms & References

English

SMQAQNWCDKDKKO-UHFFFAOYSA-N
SCHEMBL2181213
F2167-0832
AB44285
DTXSID80509526
Z1198176737
2-methylpyrazolo[1,5-a]pyrimidine
EN300-106581
78562-32-0
methylpyrazolo[1,5-a]pyrimidine
AKOS006228687
2-methyl-Pyrazolo[1,5-a]pyrimidine
2-METHYLPYRAZOLO[1,5-A]PYRIMIDINE
Pyrazolo[1,5-a]pyrimidine,2-methyl-
AG-H-15136
AK137996
CTK5E5907
SureCN2181213

MDL Number

MFCD08272070

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2-Methylpyrazolo[1,5-a]pyrimidine (CAS: 78562-32-0)?

2-Methylpyrazolo[1,5-a]pyrimidine is a crystalline solid with a molecular weight of approximately 153.16 g/mol. It has a low solubility in water but good solubility in organic solvents like ethanol and dichloromethane. The compound is moderately reactive, particularly towards nucleophiles, and is prone to condensation reactions. It exhibits good thermal stability but can decompose under strong basic conditions.

How is 2-Methylpyrazolo[1,5-a]pyrimidine (CAS: 78562-32-0) typically synthesized?

2-Methylpyrazolo[1,5-a]pyrimidine can be synthesized via the condensation of 2-methylpyrazole with urea in the presence of a strong base like sodium hydride. The reaction is typically carried out in anhydrous conditions to enhance yield and selectivity. The overall process is known for its good yield and controlled reactivity.

What industries use 2-Methylpyrazolo[1,5-a]pyrimidine (CAS: 78562-32-0)?

2-Methylpyrazolo[1,5-a]pyrimidine finds applications in the pharmaceutical industry, particularly in the synthesis of various bioactive compounds. It is also used in the development of sensors and in the production of polymer materials due to its unique chemical properties.

What precautions should be taken when handling 2-Methylpyrazolo[1,5-a]pyrimidine (CAS: 78562-32-0)?

When handling 2-Methylpyrazolo[1,5-a]pyrimidine, it is essential to wear personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be neutralized with an appropriate base and then cleaned up with care. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.