3-Hydroxyphenylalanine

Basic Information

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CAS Number

775-06-4

Molecular Formula

C9H11NO3

Molecular Weight

181.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Solid

Melting Point

280-285 °C (dec.)

Boiling Point

314.29°C (rough estimate)

Density

1.2375 (rough estimate)

Flash Point

STABILITY

Solubility

Soluble in 1M HCl.

Refractive Index

1.5270 (estimate)

SMILES

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C1=CC(=CC(=C1)O)CC(C(=O)O)N

InChI

InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-2-1-3-7(11)4-6/h1-4,8,11H,5,10H2,(H,12,13)

InChIKey

JZKXXXDKRQWDET-UHFFFAOYSA-N

LogP

0.3466

Topological Polar Surface Area

83.55 Å²

Hydrogen Bond Donor/Acceptor

4 / 4

Complexity

184

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

M02556
T0787
m-Tyrosine, DL- (8CI)
3-TYROSINE, DL-
s6061
DL-Phenylalanine, 3-hydroxy-
D,L-Metatyrosine
H-DL-Phe(3-OH)-OH
N-HYDROXY-2-METHOXYBENZENECARBOXIMIDAMIDE
SCHEMBL458080
BRN 2416853
AKOS000187893
AB15920
2-amino-3-(3-hydroxyphenyl)propanoic acid
AM20041160
AB00236
CS-W001940
45KGG1D4BI
3-(3-Hydroxyphenyl)-DL-alanine
FT-0675714
UNII-45KGG1D4BI
T-9040
L-3-hydroxyphenylalanine
DL-METATYROSINE
AC-19159
FT-0625492
DL-m-Tyrosine, crystalline
3-Hydroxy-DL-Phenylalanine
(+/-)-2-Amino-3-(3-hydroxyphenyl)propionic acid
4-14-00-02259 (Beilstein Handbook Reference)
WLN: QVYZ1R CQ

MDL Number

MFCD00002597

Customs Code

2922509090

FAQ

What are the physical and chemical properties of 3-Hydroxyphenylalanine (CAS: 775-06-4)?

3-Hydroxyphenylalanine (CAS: 775-06-4) is a white crystalline powder with a molecular weight of approximately 151.16 g/mol. It is slightly soluble in water and ethanol but only sparingly soluble in organic solvents. Chemically, it exhibits reactivity typical of phenolic compounds, making it prone to oxidation under certain conditions.

How is 3-Hydroxyphenylalanine (CAS: 775-06-4) typically synthesized?

3-Hydroxyphenylalanine (CAS: 775-06-4) is typically synthesized through the β-oxidation of phenylalanine by D-phenylalanine dehydrogenase or via the condensation of homogentisic acid with glycine. The synthesis often involves the use of enzymes or chemical reagents to achieve high selectivity and yield.

What industries use 3-Hydroxyphenylalanine (CAS: 775-06-4)?

3-Hydroxyphenylalanine (CAS: 775-06-4) is used in the pharmaceutical industry for its precursor role in the synthesis of L-dopa, a treatment for Parkinson's disease. It is also utilized in the food industry as a flavor enhancer and in various chemical industries for the production of polymers and other organic compounds.

What precautions should be taken when handling 3-Hydroxyphenylalanine (CAS: 775-06-4)?

When handling 3-Hydroxyphenylalanine (CAS: 775-06-4), wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a dry, well-ventilated place and avoid direct contact with skin and eyes. Use a fume hood for all operations to minimize exposure. In case of a spill, handle it according to the Material Safety Data Sheet (MSDS) guidelines.