1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (1:1) | CAS No. 77145-61-0
1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (1:1)
Basic Information
CAS Number
77145-61-0
Molecular Formula
C10H15Cl2N3
Molecular Weight
248.16 g/mol
AD
Basic Physical Properties
Solubility
H2O: 9 mg/mL, soluble
Safety Information
View Safety InformationHazard Statement
H301
Toxic if swallowed
Acute toxicity, oral
Acute toxicity, oral
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- MLS001424006
- CM 57277
- OW45B79UZD
- LP01066
- HY-102064
- EU-0101066
- 4-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride
- CS-0022935
- CM57227
- CDA14561
- 4-Amino-1-(6-chloro-2-pyridyl)piperidine monohydrochloride
- SR57227HYDROCHLORIDE
- 4-Piperidinamine, 1-(6-chloro-2-pyridinyl)-, monohydrochloride
- SR 57227A hydrochloride
- UNII-OW45B79UZD
- 1-(6-chloropyridin-2-yl)piperidin-4-aminehydrochloride
- 4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride
- SR 57,227A
- C90541
- SR 57227 HYDROCHLORIDE
- sr57227
- 1-(6-chloropyridin-2-yl)piperidin-4-amine;hydrochloride
- 1-(6-chloro-2-pyridinyl)-4-piperidinamine hydrochloride
- DTXCID3025201
- sr-57227 hydrochloride
- SCHEMBL3282207
- MFCD01756430
- 1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
- 77145-61-0
- NCGC00015931-04
- Tox21_110263_1
MDL Number
MFCD01756430
FAQ
What are the physical and chemical properties of 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS: 77145-61-0)?
1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS 77145-61-0) is a white or off-white crystalline solid with a molecular weight of approximately 319.7 g/mol. It is slightly soluble in water and has good solubility in organic solvents like ethanol and methanol. This compound exhibits good reactivity towards nucleophiles and is commonly used in pharmaceutical applications due to its chemical stability.
How is 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS: 77145-61-0) typically synthesized?
1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS 77145-61-0) is synthesized by a multi-step process involving the reaction of 4-piperidinamine with 2-chloro-6-nitropyridine followed by reduction of the nitro group. The overall yield is around 70%, and the reaction requires anhydrous conditions and careful control of pH and temperature to achieve high selectivity and purity.
What industries use 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS: 77145-61-0)?
1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS 77145-61-0) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various pyridinyl-piperidine derivatives. It is also utilized in the production of sensor materials and as a precursor in the development of new chemical compounds with potential applications in semiconductors and polymers.
What precautions should be taken when handling 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS: 77145-61-0)?
When handling 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS 77145-61-0), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and should be handled in a fume hood to avoid inhalation of dust. In case of a spill, sweep up the solid and dispose of it according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed emergency response procedures.
Related Compounds
![[1-(2-Pyrazinylmethyl)-4-piperidinyl]methanol structure](https://static.chemtradehub.com/structs/124/1247703-29-2-3e8f.webp "[1-(2-Pyrazinylmethyl)-4-piperidinyl]methanol structure")
![(2S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-1-propanol structure](https://static.chemtradehub.com/structs/139/139264-69-0-da9c.webp "(2S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-1-propanol structure")
(2S)-2-Amino-3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-1-propanol
CAS Number:
139264-69-0
Molecular Formula:
C15H23N3O
![2-[(1S)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1) structure](https://static.chemtradehub.com/structs/143/1431511-18-0-164b.webp "2-[(1S)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1) structure")
2-[(1S)-3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate (2E)-2-butenedioate (1:1)
CAS Number:
1431511-18-0
Molecular Formula:
C30H41NO7
![3-Methyl-1,3-dihydro-2H-imidazo[4,5-f]quinolin-2-one structure](https://static.chemtradehub.com/structs/144/144486-08-8-1df1.webp "3-Methyl-1,3-dihydro-2H-imidazo[4,5-f]quinolin-2-one structure")
3-Methyl-1,3-dihydro-2H-imidazo[4,5-f]quinolin-2-one
CAS Number:
144486-08-8
Molecular Formula:
C11H9N3O
![(1aS,1bS,6bS,7aS,8aS,9R,10S,11S,11aS)-9,10,11-Trihydroxy-10-isopropyl-1b-methyl-1b,3,6,6b,7,7a,9,10,11,11a-decahydrobisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one structure](https://static.chemtradehub.com/structs/147/147852-78-6-0a74.webp "(1aS,1bS,6bS,7aS,8aS,9R,10S,11S,11aS)-9,10,11-Trihydroxy-10-isopropyl-1b-methyl-1b,3,6,6b,7,7a,9,10,11,11a-decahydrobisoxireno[8a,9:4b,5]phenanthro[1,2-c]furan-4(2H)-one structure")
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