1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (1:1)(CAS: 77145-61-0)

1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS 77145-61-0) is a white or off-white crystalline solid with a molecular weight of approximately 319.7 g/mol. It is slightly soluble in water and has good solubility in organic solvents like ethanol and methanol. This compound exhibits good reactivity towards nucleophiles and is commonly used in pharmaceutical applications due to its chemical stability.

1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS 77145-61-0) is synthesized by a multi-step process involving the reaction of 4-piperidinamine with 2-chloro-6-nitropyridine followed by reduction of the nitro group. The overall yield is around 70%, and the reaction requires anhydrous conditions and careful control of pH and temperature to achieve high selectivity and purity.

1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS 77145-61-0) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various pyridinyl-piperidine derivatives. It is also utilized in the production of sensor materials and as a precursor in the development of new chemical compounds with potential applications in semiconductors and polymers.

When handling 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride (CAS 77145-61-0), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and should be handled in a fume hood to avoid inhalation of dust. In case of a spill, sweep up the solid and dispose of it according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed emergency response procedures.