Azithromycin EP Impurity A (Azathramycin, Desmethyl Azithromycin)

Basic Information

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CAS Number

76801-85-9

Molecular Formula

C37H70N2O12

Molecular Weight

734.97 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

126-136°C

Boiling Point

815.2°C at 760 mmHg

Density

1.18

SMILES

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CCC1C(C(C(NCC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O

InChI

InChI=1S/C37H70N2O12/c1-14-26-37(10,45)30(41)23(6)38-18-19(2)16-35(8,44)32(51-34-28(40)25(39(11)12)15-20(3)47-34)21(4)29(22(5)33(43)49-26)50-27-17-36(9,46-13)31(42)24(7)48-27/h19-32,34,38,40-42,44-45H,14-18H2,1-13H3/t19-,20-,21+,22-,23-,24+,25+,26-,27+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChIKey

HRKNNHYKWGYTEN-HOQMJRDDSA-N

LogP

1.5585000000000058

Topological Polar Surface Area

188.86999999999998 Å²

Hydrogen Bond Donor/Acceptor

6 / 14

Complexity

1120

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DESMETHYL
Azaerythromycin A
AKOS025401474
9-Deoxo-9a-aza-9a-homo Erythromycin A Desmethyl Azithromycin
4LSP9FJT5B
DESMETHYL AZITHROMYCIN
Azaerythromycin
CS-1474
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
10-Dihydro-10-deoxo-11-azaerythromycin A
MFCD09038719
6-Demethylazithromycin (Azaerythromycin A)
9-Deoxo-9a-aza-9a-homoerythromycin A
CHEMBL1222181
AZAERYTHROMYCIN A [USP-RS]
2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methylhexopyranoside
SCHEMBL6920246
DTXSID30998123
EC 616-385-9
AZITHROMYCIN IMPURITY A [EP IMPURITY]
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(4-Dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-3,4,10-trihydroxy-13-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
s4978
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
HRKNNHYKWGYTEN-HOQMJRDDSA-N
HY-17442
CCG-270420
(Desmethyl Azithromycin)
AC-18936
76801-85-9
desmethyl-azithromycin
Azathramycin

MDL Number

MFCD09038719

FAQ

What is Azithromycin EP Impurity A (CAS: 76801-85-9)?

Azithromycin EP Impurity A, also known as Azathramycin or Desmethyl Azithromycin, is a chemical impurity found in Azithromycin, a macrolide antibiotic. It does not have a distinct chemical formula separate from its parent compound but is a degradation product. It is colorless to light yellow crystals or a white to off-white powder.

What are the main uses of Azithromycin EP Impurity A (CAS: 76801-85-9)?

Azithromycin EP Impurity A is not used directly for therapeutic purposes. It is of interest in pharmaceutical quality control, as its presence can indicate the purity of Azithromycin. It is analyzed to ensure that the drug meets the necessary quality standards.

Is Azithromycin EP Impurity A (CAS: 76801-85-9) safe?

Azithromycin EP Impurity A, while derived from Azithromycin, is generally not considered toxic. However, it should be handled with care due to the potential for skin and eye irritation. Proper protective measures, such as gloves and safety glasses, should be used during handling. It is not classified as a hazardous material under standard safety regulations.

How should Azithromycin EP Impurity A (CAS: 76801-85-9) be stored?

Azithromycin EP Impurity A should be stored in a cool, dark place to prevent degradation. It should be kept in a tightly sealed container to protect against moisture. Ideal storage conditions are a temperature range of 15-25°C (59-77°F) and a relative humidity below 65%. Avoid exposure to light and heat to maintain its stability.