Aciclovir (Acyclovir) EP Impurity G (Acyclovir USP Related Compound G)

Basic Information

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CAS Number

75128-73-3

Molecular Formula

C12H15N5O5

Molecular Weight

309.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

204 ºC

Density

1.53

SMILES

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CC(=O)NC1=NC2=C(C(=O)N1)N=CN2COCCOC(=O)C

InChI

InChI=1S/C12H15N5O5/c1-7(18)14-12-15-10-9(11(20)16-12)13-5-17(10)6-21-3-4-22-8(2)19/h5H,3-4,6H2,1-2H3,(H2,14,15,16,18,20)

InChIKey

VBHLKZHSCMQLTI-UHFFFAOYSA-N

LogP

-0.38480000000000003

Topological Polar Surface Area

128.2 Å²

Hydrogen Bond Donor/Acceptor

2 / 10

Complexity

494

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

75128-73-3
ACETAMIDE, N-(9-((2-(ACETYLOXY)ETHOXY)METHYL)-6,9-DIHYDRO-6-OXO-1H-PURIN-2-YL)-
2-{[2-(acetylamino)-6-oxo-1,6-dihydro-9H-purin-9-yl]methoxy}ethyl acetate
EINECS 278-077-7
SCHEMBL11550890
2-[(2-Acetamido-6-oxo-6,9-dihydro-1H-purin-9-yl)methoxy]ethyl acetate
N,O-Diacetylacyclovir
2-[(2-Acetamido-6-oxo-1H-purin-9(6H)-yl)methoxy]ethyl Acetate
W-104398
2-((2-Acetamido-6-oxo-1H-purin-9(6H)-yl)methoxy)-ethyl acetate
ACICLOVIR IMPURITY G [WHO-IP]
PD014245
MFCD00267706
N2-ACETYL-9-[(2'-ACETOXYETHOXY)METHYL]GUANINE
HMS2309O20
AG-205/25000980
SR-01000401986
MLS000030665
DTXSID40226085
U32280404H
CS-0136972
VBHLKZHSCMQLTI-UHFFFAOYSA-N
2-((2-Acetamido-6-oxo-1H-purin-9(6H)-yl)methoxy)ethyl acetate
FT-0641554
UNII-U32280404H
SR-01000401986-1
AC-972
N2-Acetyl-9-(2-acetoxyethoxymethyl)guanine (Acyclovir Impurity)
9-[(2-Acetoxyethoxy)methyl]-N2-acetylguanine
CHEMBL1303813
SMR000009008

MDL Number

MFCD00267706

FAQ

What is Aciclovir (Acyclovir) EP Impurity G (CAS: 75128-73-3)?

Aciclovir (Acyclovir) EP Impurity G (CAS: 75128-73-3) is an acyclic nucleoside analog used as an impurity in pharmaceutical manufacturing. Its chemical formula is C8H12N4O3, and it is structurally related to Aciclovir, differing by a methyl group. This compound is commonly identified during drug quality control and regulatory analysis to ensure product purity and safety.

What are the main uses of Aciclovir (Acyclovir) EP Impurity G (CAS: 75128-73-3)?

Aciclovir (Acyclovir) EP Impurity G (CAS: 75128-73-3) is primarily used in pharmaceuticals for impurity testing in Aciclovir drug formulations. It also serves as a reference standard in analytical research to assess purity, compliance with EP and USP guidelines, and to study degradation pathways during drug development and stability testing.

Is Aciclovir (Acyclovir) EP Impurity G (CAS: 75128-73-3) safe?

Aciclovir (Acyclovir) EP Impurity G (CAS: 75128-73-3) is considered safe when handled properly in controlled environments. However, as an impurity, it may exhibit toxicity depending on exposure levels. Safety measures include wearing protective gear, avoiding inhalation or skin contact, and adhering to ICH and USP safety standards during pharmaceutical processing.

How should Aciclovir (Acyclovir) EP Impurity G (CAS: 75128-73-3) be stored?

Aciclovir (Acyclovir) EP Impurity G (CAS: 75128-73-3) should be stored in a cool, dry place at 20-25°C, protected from light. Keep in a sealed container to prevent moisture ingress and contamination. Proper storage ensures stability and minimizes degradation, maintaining its integrity for analytical and pharmaceutical applications.