2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride

Basic Information

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CAS Number

73218-79-8

Molecular Formula

C9H11Cl3N4

Molecular Weight

281.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

>2300C

Solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL Solutions may be stored for several days at 4?#x00b0;C

SMILES

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C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl.Cl

InChI

InChI=1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2,12H2,(H2,13,14,15);1H

InChIKey

OTQYGBJVDRBCHC-UHFFFAOYSA-N

LogP

2.3684999999999996

Topological Polar Surface Area

62.44 Å²

Hydrogen Bond Donor/Acceptor

4 / 4

Complexity

247

Safety Information

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Hazard Statement

Hazard Class

Class 6.1(b) Class 6.1(b)

Stability

Moisture Sensitive

Synonyms & References

English

MLS000028829
APRACLONIDINE HYDROCHLORIDE (USP-RS)
Tox21_111207
FT-0602878
1,4-Benzenediamine, 2,6-Dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl), Monohydrochloride
2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride
LP00033
Apraclonidine hydrochloride [USAN]
2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine;hydrochloride
2-((4-AMINO-2,6-DICHLOROPHENYL)IMINO) IMIDAZOLIDINE MONOHYDROCHLORIDE
DTXCID4025749
2-(4-Amino-2,6-dichlorophenylimino)imidazolidine hydrochloride
SCHEMBL41138
AKOS022175501
OTQYGBJVDRBCHC-UHFFFAOYSA-N
2-[(2,6-dichloro-4-aminophenyl)imino]imidazolidine hydrochloride
AL02145
2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-
APRACLONIDINE HYDROCHLORIDE [ORANGE BOOK]
APRACLONIDINE HYDROCHLORIDE [USP MONOGRAPH]
2,6-bis(chloranyl)-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride
A837749
APRACLONIDINE HYDROCHLORIDE (USP IMPURITY)
73218-79-8 (Apraclonidine HCl)
p-Aminoclonidine hydrochloride, solid
2-((4-Amino-2,6-dichlorophenyl)imino)imidazolidine monohydrochloride
BA164186
C76333
Apraclonidine hydrochloride [USAN:USP]
2,6-Dichloro-N(1)-(2-imidazolidinylidene)-1,4-benzenediamine hydrochloride
APRACLONIDINE HYDROCHLORIDE [MART.]

MDL Number

MFCD00135922

Customs Code

2933290090

FAQ

What are the physical and chemical properties of 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride (CAS: 73218-79-8)?

2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride (CAS: 73218-79-8) is a white or off-white crystalline solid with a molecular weight of approximately 351.24 g/mol. It has a solubility of about 0.1 g/L in water and is moderately basic. The compound is known for its reactivity towards nucleophiles and electrophiles. It exhibits good stability in air and under normal storage conditions.

How is 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride (CAS: 73218-79-8) typically synthesized?

2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride (CAS: 73218-79-8) is typically synthesized via the condensation of 2-chloro-6-dimethylaminobenzaldehyde with 2-aminomethyl-4,5-dihydro-1H-imidazole. The reaction is catalyzed by acid or base and proceeds with good yield. The product is often purified by recrystallization from water or aqueous alcohol solutions.

What industries use 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride (CAS: 73218-79-8)?

2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride (CAS: 73218-79-8) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various imidazole-containing compounds. It also finds applications in the polymer and sensor industries where its unique chemical properties are exploited.

What precautions should be taken when handling 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride (CAS: 73218-79-8)?

When handling 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride (CAS: 73218-79-8), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up with caution, using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information and guidance.