6-(2,2,2-Trifluoroethoxy)-3-pyridinamine

Basic Information

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CAS Number

72617-82-4

Molecular Formula

C7H7F3N2O

Molecular Weight

192.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

247.9±40.0 ºC (760 Torr),

Density

1.354±0.06 g/cm3 (20 ºC 760 Torr),

Flash Point

103.7±27.3 ºC,

SMILES

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C1=CC(=NC=C1N)OCC(F)(F)F

InChI

InChI=1S/C7H7F3N2O/c8-7(9,10)4-13-6-2-1-5(11)3-12-6/h1-3H,4,11H2

InChIKey

OJCXGRPKFISGAZ-UHFFFAOYSA-N

LogP

1.6049

Topological Polar Surface Area

48.14 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

162

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Z240084298
EN300-41019
AM20120540
3-Pyridinamine, 6-(2,2,2-trifluoroethoxy)-
5-Amino-2-[2,2,2-trifluoroethoxy]pyridine
6-(2,2,2-Trifluoro-ethoxy)-pyridin-3-ylamine
BS-13802
6-(2,2,2-trifluoroethoxy)pyridin-3-amine
SCHEMBL10092
CS-W003148
DTXSID10337511
AC-29335
5-amino-2-(2,2,2trifluoroethoxy)pyridine
IDI1_016390
SY020669
6-(2,2,2-Trifluoroethoxy)-3-pyridinamine #
Maybridge3_005003
C7H7F3N2O
MFCD04111379
AKOS000150658
HMS1445D09
2-(2,2,2-Trifluoroethoxy)-5-aminopyridine
6-(2,2,2-Trifluoroethoxy)-3-pyridinamine
A854653
AB17532
72617-82-4
6-(2,2,2-Trifluoroethoxy)pyridin-3-amine
[6-(2,2,2-Trifluoroethoxy)pyridin-3-yl]amine
OJCXGRPKFISGAZ-UHFFFAOYSA-N
6-(2,2,2-trifluoroethoxy)-3-pyridylamine
SBB026576

MDL Number

MFCD04111379

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 6-(2,2,2-Trifluoroethoxy)-3-pyridinamine (CAS: 72617-82-4)?

6-(2,2,2-Trifluoroethoxy)-3-pyridinamine (CAS: 72617-82-4) is a crystalline solid with a molecular weight of approximately 264.16 g/mol. It has a low solubility in water but is miscible with organic solvents like ethanol and acetone. This compound exhibits moderate reactivity, particularly towards nucleophiles. It is stable under normal conditions but should be stored in a cool, dry place to avoid moisture and heat.

How is 6-(2,2,2-Trifluoroethoxy)-3-pyridinamine (CAS: 72617-82-4) typically synthesized?

6-(2,2,2-Trifluoroethoxy)-3-pyridinamine (CAS: 72617-82-4) can be synthesized via a multi-step process involving the reaction of 2,2,2-trifluoroethanol with 3-chloropyridine followed by amino substitution. Common catalysts include sodium hydride, and the overall yield can range from 50-70%. The reaction is susceptible to side reactions, so high purity reagents and careful pH control are essential.

What industries use 6-(2,2,2-Trifluoroethoxy)-3-pyridinamine (CAS: 72617-82-4)?

6-(2,2,2-Trifluoroethoxy)-3-pyridinamine (CAS: 72617-82-4) finds applications in pharmaceuticals, particularly in the synthesis of certain drug intermediates, as well as in the development of sensors and semiconductors. Its unique chemical structure makes it a valuable reagent in polymer chemistry for modifying material properties.

What precautions should be taken when handling 6-(2,2,2-Trifluoroethoxy)-3-pyridinamine (CAS: 72617-82-4)?

When handling 6-(2,2,2-Trifluoroethoxy)-3-pyridinamine (CAS: 72617-82-4), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood. Spills should be cleaned up immediately and handled according to safety data sheet (SDS) guidelines. Proper disposal and storage should follow local regulations to ensure environmental safety.