3-Chloro-2-methylpyridine

Basic Information

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CAS Number

72093-03-9

Molecular Formula

C6H6ClN

Molecular Weight

127.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

156.5℃ at 760 mmHg

Flash Point

60.2℃

SMILES

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CC1=C(C=CC=N1)Cl

InChI

InChI=1S/C6H6ClN/c1-5-6(7)3-2-4-8-5/h2-4H,1H3

InChIKey

YSEYOMUPVMGJPP-UHFFFAOYSA-N

LogP

2.04342

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

74.9

Synonyms & References

English

AC-23062
DTXSID00376459
AM62479
AB17903
EN300-88416
MFCD04114121
FT-0649129
J-512204
3-chloro-2-methylpyridine
AKOS006295148
SY013090
Pyridine, 3-chloro-2-methyl-
CS-W003156
3-chloro-2-methyl-pyridine
SCHEMBL111141
TS-01675
Methylpyridinchlorid
PotassiumN-methyldithiocarbamate
A837420
3-Chloro-2-picoline
72093-03-9
3-Chloro-2-methylpyridine
Pyridine,3-chloro-2-methyl-
PubChem14380
3-chloranyl-2-methyl-pyridine
3-CHLORO-2-METHYL PYRIDINE
SBB054401
RP19761
VP13830
BC656264

MDL Number

MFCD04114121

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-Chloro-2-methylpyridine (CAS: 72093-03-9)?

3-Chloro-2-methylpyridine is a crystalline solid with a molecular weight of 147.57 g/mol. It has low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, particularly with strong bases and nucleophiles. It can form complexes with metals and undergo electrophilic substitution reactions.

How is 3-Chloro-2-methylpyridine (CAS: 72093-03-9) typically synthesized?

3-Chloro-2-methylpyridine is commonly synthesized through the chlorination of 2-methylpyridine in the presence of thionyl chloride. An alternative method involves the reaction of 2-methylpyridine with chlorine gas in the presence of a Lewis acid catalyst, such as aluminum chloride. These methods provide good yields, with high selectivity towards the chlorinated product.

What industries use 3-Chloro-2-methylpyridine (CAS: 72093-03-9)?

3-Chloro-2-methylpyridine is used in the pharmaceutical industry as a precursor for the synthesis of certain drugs. It also finds applications in the polymer industry, where it serves as a monomer for the production of polymers. Additionally, it is utilized in the development of sensors and in the electronics industry for its use in semiconductor manufacturing.

What precautions should be taken when handling 3-Chloro-2-methylpyridine (CAS: 72093-03-9)?

When handling 3-Chloro-2-methylpyridine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled carefully, using appropriate absorbents, and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.