2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone

Basic Information

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CAS Number

711-38-6

Molecular Formula

C9H7F3O2

Molecular Weight

204.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

64°C/0.5mm

Density

1.319

Flash Point

94.6 °C

Refractive Index

1.4970 to 1.5020

SMILES

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COC1=CC=C(C=C1)C(=O)C(F)(F)F

InChI

InChI=1S/C9H7F3O2/c1-14-7-4-2-6(3-5-7)8(13)9(10,11)12/h2-5H,1H3

InChIKey

NCJZVRPXSSYDBG-UHFFFAOYSA-N

LogP

2.4402

Topological Polar Surface Area

26.3 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

205

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

NSC55522
MFCD00018061
DTXSID00221319
NSC 55522
ETHANONE, 2,2,2-TRIFLUORO-1-(4-METHOXYPHENYL)-
2,2,2-trifluoro-1-(4-methoxyphenyl)ethanone
4-(Trifluoroacetyl)anisole
NSC-55522
FS-1687
4'-Methoxy-2,2,2-trifluoroacetophenone
2,2,2-Trifluoro-4'-methoxyacetophenone
2,2,2-trifluoro-1-(4-methoxyphenyl)-ethanone
AC-27939
FT-0632865
A837091
711-38-6
4-trifluoroacetylanisole
T1986
AB01248
AM20041061
SCHEMBL1398393
SY046327
CS-0028395
2,2,2-Trifluoro-4 inverted exclamation mark -methoxyacetophenone
CHEMBL2289157
2,2,2-trifluoro-1-(4-methoxyphenyl)ethan-1-one
p-methoxy-a,a,a-trifluoroacetophenone
AKOS005259360
2,2,2-Trifluoro-1-(4-methoxy-phenyl)-ethanone
2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone
Ethanone,2,2,2-trifluoro-1-(4-methoxyphenyl)-

MDL Number

MFCD00018061

Customs Code

2914700090

FAQ

What are the physical and chemical properties of 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6)?

2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6) is a colorless to white crystalline solid with a molecular weight of 252.21 g/mol. It has a low solubility in water but is soluble in common organic solvents like dichloromethane, methanol, and acetonitrile. This compound is chemically stable but can react with strong bases. It is not flammable but may release toxic fumes upon decomposition.

How is 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6) typically synthesized?

2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6) is typically synthesized via a Friedel-Crafts acylation reaction, where 4-methoxybenzoyl chloride reacts with trifluoroacetyl chloride in the presence of aluminum chloride as a catalyst. The reaction is carried out at low temperatures, and the product is obtained with good yield and selectivity.

What industries use 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6)?

2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6) is used in the pharmaceutical industry for the synthesis of various drug candidates. It is also utilized in the polymer industry for the development of advanced materials, and in the sensor and semiconductor industries for specific applications requiring high purity and stability.

What precautions should be taken when handling 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6)?

Proper handling of 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6) requires wearing appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood. In case of a spill, use appropriate absorbent materials and follow local safety guidelines. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.