Compound Q&A

How is 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6) typically synthesized?

Answer

2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone
2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone (CAS: 711-38-6) is typically synthesized via a Friedel-Crafts acylation reaction, where 4-methoxybenzoyl chloride reacts with trifluoroacetyl chloride in the presence of aluminum chloride as a catalyst. The reaction is carried out at low temperatures, and the product is obtained with good yield and selectivity.

About

CAS No 711-38-6
English Name 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone
Molecular Formula C9H7F3O2
Molecular Weight 204.14699999999993 g/mol
SMILES COC1=CC=C(C=C1)C(=O)C(F)(F)F
InChIKey NCJZVRPXSSYDBG-UHFFFAOYSA-N
Last Updated: 2025-10-28 15:15

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