4-Chloro-7-methoxyquinoline

Basic Information

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CAS Number

68500-37-8

Molecular Formula

C10H8ClNO

Molecular Weight

193.63 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

75-77

Boiling Point

299.8°C at 760 mmHg

Flash Point

135.163℃

SMILES

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COC1=CC2=NC=CC(=C2C=C1)Cl

InChI

InChI=1S/C10H8ClNO/c1-13-7-2-3-8-9(11)4-5-12-10(8)6-7/h2-6H,1H3

InChIKey

UKTYNFPTZDSBLR-UHFFFAOYSA-N

LogP

2.8968000000000007

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

176

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

UKTYNFPTZDSBLR-UHFFFAOYSA-N
EN300-88493
7-Methoxy-4-chloroquinoline
SY003966
Z414834566
Q-102325
68500-37-8
FS-2270
AKOS002683687
FT-0600677
4-Chloro-7-methoxy-quinoline
AC-3133
4-Chloro-7-methoxyquinoline, AldrichCPR
PB12379
DTXSID90442394
CHEMBL4468786
MFCD06659036
A9116
(4-chloroquinolin-7-yl)methyl ether
4-chloro-7-methoxyquinoline
SCHEMBL201122
AMY325
QUINOLINE, 4-CHLORO-7-METHOXY-
CS-W003314
4-Chloro-7-methoxyquinoline
7-methoxy-4-chloro-quinoline
4-Chlor-7-methoxy-chinolin
4-Cholro-7-methoxyquinoline

MDL Number

MFCD06659036

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 4-Chloro-7-methoxyquinoline (CAS: 68500-37-8)?

4-Chloro-7-methoxyquinoline (CAS: 68500-37-8) is a crystalline solid with a molecular weight of approximately 213.57 g/mol. It has a melting point around 180°C and is slightly soluble in water. Chemically, it is reactive towards nucleophiles and can participate in electrophilic aromatic substitution reactions.

How is 4-Chloro-7-methoxyquinoline (CAS: 68500-37-8) typically synthesized?

4-Chloro-7-methoxyquinoline (CAS: 68500-37-8) is commonly synthesized via the reaction of 7-methoxyquinoline with thionyl chloride followed by hydrolysis. This method provides good yield and selectivity, with the reaction being monitored by TLC or HPLC.

What industries use 4-Chloro-7-methoxyquinoline (CAS: 68500-37-8)?

4-Chloro-7-methoxyquinoline (CAS: 68500-37-8) is used in the pharmaceutical industry for the synthesis of certain drugs. It is also applied in the polymer industry for the development of new materials with specific properties and in the semiconductor industry for its use in organic electronics.

What precautions should be taken when handling 4-Chloro-7-methoxyquinoline (CAS: 68500-37-8)?

When handling 4-Chloro-7-methoxyquinoline (CAS: 68500-37-8), it is important to wear appropriate personal protective equipment (PPE) including gloves and goggles. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling instructions.