2-Bromo-1-(2-fluorophenyl)ethanone

Basic Information

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CAS Number

655-15-2

Molecular Formula

C8H6BrFO

Molecular Weight

217.04 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

25-30 °C

Boiling Point

63°C/0.03mmHg

Density

1.574 g/mL at 25 °C

Refractive Index

n20/D 1.563

SMILES

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C1=CC=C(C(=C1)C(=O)CBr)F

InChI

InChI=1S/C8H6BrFO/c9-5-8(11)6-3-1-2-4-7(6)10/h1-4H,5H2

InChIKey

QDNWNJSLWKHNTM-UHFFFAOYSA-N

LogP

2.4033000000000007

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

149

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Lachrymatory

Synonyms & References

English

MFCD00278796
AKOS000122304
FT-0632763
AM1122
2-Bromo-2 inverted exclamation mark -fluoroacetophenone
Ethanone, 2-bromo-1-(2-fluorophenyl)-
QDNWNJSLWKHNTM-UHFFFAOYSA-N
DTXSID40372071
BCP28127
METHYL3-AMINO-4-(ISOPROPYLSULFONYL)-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE
2-Bromo-2'-fluoroacetophenone, 97%
PS-9994
HY-W004082
2-bromo-1-(2-fluorophenyl)-ethanone
Z94602027
2-fluorophenacyl bromide, AldrichCPR
2-FLUOROPHENACYL BROMID
2-bromo-1-(2-fluoro-phenyl)-ethanone
2-Bromo-2'-fluoroacetophenone
EN300-01886
2'-fluoro-bromoacetophenone
2-Fluorophenacyl bromide
B5104
2-Fluorophenacylbromide
CS-W004082
655-15-2
A835139
SY022607
SCHEMBL166429
2-bromo-1-(2-fluorophenyl)ethan-1-one
o-fluoro phenacyl bromide

MDL Number

MFCD00278796

Customs Code

2914700090

FAQ

What are the physical and chemical properties of 2-Bromo-1-(2-fluorophenyl)ethanone (CAS: 655-15-2)?

2-Bromo-1-(2-fluorophenyl)ethanone is a crystalline solid with a molecular weight of approximately 215.02 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can undergo nucleophilic substitution reactions, particularly with alcohols and amines. The compound has a melting point of around 60-63°C and a boiling point of approximately 200°C. It reacts with bases to form bromide salts and with acids to generate ketone derivatives.

How is 2-Bromo-1-(2-fluorophenyl)ethanone (CAS: 655-15-2) typically synthesized?

2-Bromo-1-(2-fluorophenyl)ethanone is typically synthesized via a reaction of 2-bromoethanone with 2-fluorophenylboronic acid in the presence of a palladium catalyst, such as Pd(PPh3)4, in the absence of oxygen. The reaction involves a cross-coupling process, leading to high selectivity and good yield. Other methods include the direct bromination of 1-(2-fluorophenyl)ethanone using bromine, although this approach may yield lower purity products.

What industries use 2-Bromo-1-(2-fluorophenyl)ethanone (CAS: 655-15-2)?

2-Bromo-1-(2-fluorophenyl)ethanone finds applications in various industries, particularly in the pharmaceutical sector for the synthesis of complex organic molecules. It is also used in polymer chemistry for the modification of polymers, in the development of sensors for detecting specific chemicals, and in semiconductor manufacturing for the production of materials with unique electronic properties.

What precautions should be taken when handling 2-Bromo-1-(2-fluorophenyl)ethanone (CAS: 655-15-2)?

When handling 2-Bromo-1-(2-fluorophenyl)ethanone, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled carefully using absorbent materials, followed by proper disposal according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.