Ethyl azidoacetate

Basic Information

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CAS Number

637-81-0

Molecular Formula

C4H7N3O2

Molecular Weight

129.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Boiling Point

164°C

Density

1.127 g/mL at 25 °C

Refractive Index

1.4330 to 1.4370

SMILES

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O=C(OCC)CN=[N+]=[N-]

InChI

InChI=1S/C4H7N3O2/c1-2-9-4(8)3-6-7-5/h2-3H2,1H3

InChIKey

HVJJYOAPXBPQQV-UHFFFAOYSA-N

LogP

0.31256

Complexity

139

Safety Information

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Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 3 Class 3

Synonyms & References

English

Acetic acid, 2-azido-,ethyl ester
Ethyl Azidoacetate
ethyl2-azidoacetate
Ethyl azidoacetate solution
Azidoacetic Acid Ethyl Ester
Ethyl 2-azidoacetate
Acetic acid, azido-, ethyl ester
Azido-acetic acid ethyl ester
Ethyl azidoacetate, 25% solution in toluene
ethyl azido-acetate
ethyl-2-azidoacetate
Ethylazidoacetatesolution
ethyl alpha-azidoacetate
NCIOpen2_000977
azido acetic acid ethyl ester

MDL Number

MFCD00190177

Customs Code

2929909090

FAQ

What are the physical and chemical properties of Ethyl azidoacetate (CAS: 637-81-0)?

Ethyl azidoacetate (CAS: 637-81-0) is a colorless to slightly yellow liquid with a molecular weight of approximately 110.11 g/mol. It has a pungent odor and is highly soluble in water and organic solvents. Chemically, it is reactive and can undergo nucleophilic substitution reactions. It is also unstable to light and heat, decomposing into acetic acid and azide ion.

How is Ethyl azidoacetate (CAS: 637-81-0) typically synthesized?

Ethyl azidoacetate is typically synthesized by reacting acetyl chloride with sodium azide in an aprotic solvent like dimethylformamide (DMF). The reaction is catalyzed by a base such as potassium carbonate and occurs at room temperature. The yield is usually around 85-90%, and the product is purified by recrystallization or distillation.

What industries use Ethyl azidoacetate (CAS: 637-81-0)?

Ethyl azidoacetate is used in various industries, including pharmaceuticals for drug synthesis, polymers for modifying polymers, sensors for detecting nitrite, and semiconductors for photolithography. It plays a crucial role in these fields due to its reactivity and ability to introduce azide groups into molecules.

What precautions should be taken when handling Ethyl azidoacetate (CAS: 637-81-0)?

Handling Ethyl azidoacetate (CAS: 637-81-0) requires strict safety protocols. It should be stored in a cool, dry place away from heat and light. Personal protective equipment (PPE) such as gloves, goggles, and a lab coat must be worn. Fume hoods should be used during handling to avoid inhalation. In case of spill, immediately neutralize with a base and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.