Ethyl (4-hydroxy-2-oxo-1-pyrrolidinyl)acetate

Basic Information

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CAS Number

62613-81-4

Molecular Formula

C8H13NO4

Molecular Weight

187.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

367°C at 760 mmHg

Density

1.27

Flash Point

175.8°C

Refractive Index

1.51

SMILES

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O=C(OCC)CN1C(CC(O)C1)=O

InChI

InChI=1S/C8H13NO4/c1-2-13-8(12)5-9-4-6(10)3-7(9)11/h6,10H,2-5H2,1H3

InChIKey

YDBONCLBTWFUPF-UHFFFAOYSA-N

LogP

-0.8573000000000004

Topological Polar Surface Area

66.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

768

Synonyms & References

English

Ethyl 2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetate
ethyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate
4-Hydroxy-2-oxo-1-pyrrolidineacetic Acid Ethyl Ester
1-Pyrrolidineaceticacid, 4-hydroxy-2-oxo-, ethyl ester
ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate
OXIRACETAM IMPURITY D
oxiracetam impurity VII

MDL Number

MFCD19665570

FAQ

What are the physical and chemical properties of Ethyl (4-hydroxy-2-oxo-1-pyrrolidinyl)acetate (CAS: 62613-81-4)?

Ethyl (4-hydroxy-2-oxo-1-pyrrolidinyl)acetate (CAS: 62613-81-4) is a colorless to pale yellow liquid with a molecular weight of approximately 170.24 g/mol. It is moderately soluble in water but highly soluble in organic solvents such as methanol and ethanol. This compound is known for its high reactivity, particularly in nucleophilic substitution reactions and esterification processes.

How is Ethyl (4-hydroxy-2-oxo-1-pyrrolidinyl)acetate (CAS: 62613-81-4) typically synthesized?

Ethyl (4-hydroxy-2-oxo-1-pyrrolidinyl)acetate (CAS: 62613-81-4) can be synthesized via the condensation of 2-oxo-1-pyrrolidinyl alcohol with ethyl acetate under acidic catalysis. The synthetic process typically involves refluxing the reactants in the presence of a Lewis acid catalyst like aluminum trichloride to achieve high yield and selectivity.

What industries use Ethyl (4-hydroxy-2-oxo-1-pyrrolidinyl)acetate (CAS: 62613-81-4)?

Ethyl (4-hydroxy-2-oxo-1-pyrrolidinyl)acetate (CAS: 62613-81-4) is used in pharmaceuticals for the synthesis of certain APIs and intermediates, as well as in the formulation of topical drugs. It is also utilized in the polymer industry for modifying properties of polymers and in the production of sensors and semiconductors for its reactivity and stability.

What precautions should be taken when handling Ethyl (4-hydroxy-2-oxo-1-pyrrolidinyl)acetate (CAS: 62613-81-4)?

When handling Ethyl (4-hydroxy-2-oxo-1-pyrrolidinyl)acetate (CAS: 62613-81-4), it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be handled carefully using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.