Riociguat | CAS No. 625115-55-1

Riociguat

Basic Information

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CAS Number

625115-55-1

Molecular Formula

C20H19FN8O2

Molecular Weight

422.42 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

567.2°C at 760 mmHg

Density

1.51

SMILES

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CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC

InChI

InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)

InChIKey

WXXSNCNJFUAIDG-UHFFFAOYSA-N

LogP

2.4426999999999994

Topological Polar Surface Area

138.07 Å²

Hydrogen Bond Donor/Acceptor

4 / 10

Complexity

618

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Adempas
PB25734
Riociguat [INN]
Riociguat,CAS:625115-55-1
RIOCIGUAT [VANDF]
HY-14779
1304478-72-5
Carbamic acid, (4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl)methyl-, methyl ester
Methyl N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbaminate
RIOCIGUAT [JAN]
Adempas (TN)
Riociguat-d3
NS00069317
GTPL5257
Q2154494
Methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl(methyl)carbamate
methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
EX-A2023
C20H19FN8O2
CHEBI:76018
RIOCIGUAT [MI]
WXXSNCNJFUAIDG-UHFFFAOYSA-N
FT-0760451
[4,6-Diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]methylcarbamic acid methyl ester
NCGC00379065-05
AMY4218
GZO
RU3FE2Y4XI
Bay 63-2521,Riociguat
N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
AC-27647

MDL Number

MFCD19443708

FAQ

What is Riociguat (CAS: 625115-55-1)?

Riociguat (CAS: 625115-55-1) is a chemical compound primarily used in the treatment of pulmonary hypertension. It functions as a soluble guanylate cyclase (sGC) stimulator, enhancing the production of cyclic guanosine monophosphate (cGMP) to relax blood vessels and improve blood flow. Its chemical formula is C18H20N6O4S.

What are the main uses of Riociguat (CAS: 625115-55-1)?

Riociguat (CAS: 625115-55-1) is mainly used in pharmaceutical applications to treat pulmonary hypertension. It is also used in research for studying cardiovascular diseases and as a tool in drug development for sGC activators. Its role in improving oxygenation and reducing pulmonary artery pressure makes it a key compound in therapeutic and scientific contexts.

Is Riociguat (CAS: 625115-55-1) safe?

Riociguat (CAS: 625115-55-1) is generally considered safe when used as directed in medical settings. However, it may cause side effects such as headaches, dizziness, and hypotension. Proper handling and adherence to safety guidelines are essential, especially in laboratory environments. Safety data sheets and regulatory approvals ensure its safe use in pharmaceutical and research applications.

How should Riociguat (CAS: 625115-55-1) be stored?

Riociguat (CAS: 625115-55-1) should be stored in a cool, dry place away from direct light. It is typically kept in airtight containers to maintain its stability and prevent degradation. Storage conditions should be between 15°C to 25°C (59°F to 77°F) with low humidity to ensure optimal shelf life and potency.