Cyclophosphamide hydrate

Basic Information

View in Editor

CAS Number

6055-19-2

Molecular Formula

C7H15Cl2N2O2P.H2O

Molecular Weight

279.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Insecticides

Basic Physical Properties

Melting Point

49-51 °C

Boiling Point

110°C

Water Solubility

40 g/L

Solubility

H2O: 0.1 g/mL, clear, colorless

SMILES

View in Editor

C1CNP(=O)(OC1)N(CCCl)CCCl.O

InChI

InChI=1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

InChIKey

PWOQRKCAHTVFLB-UHFFFAOYSA-N

LogP

1.0592999999999997

Topological Polar Surface Area

73.07 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

212

Safety Information

View Safety Information

GHS Hazard Pictograms

H301

H350

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H350 May cause cancer
Carcinogenicity

Hazard Class

Class 6.1 Class 6.1

Sensitiveness

sensitive to heat, light, and air

Synonyms & References

English

NSC-756711
2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide, monohydrate, (+-)
s2057
HMS500M08
CYCLOPHOSPHAMIDE MONOHYDRATE [WHO-DD]
(+/-)-2-(BIS(2-CHLOROETHYL)AMINO)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE MONOHYDRATE
2-(Bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane 2-oxide monohydrate
N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide--water (1/1)
N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide hydrate
CHEBI:4026
Cyclophosphamide (hydrate)
CHEMBL1200796
NCGC00091741-01
NCGC00094636-04
2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate
HMS1920C04
NC00662
Cyclophosphamide (USP)
CYCLOPHOSPHAMIDUM [WHO-IP LATIN]
Tox21_201503
SMR000718805
BCP22663
SR-01000075737-4
SPECTRUM1500213
C06933
Cyclophosphamide hydrate
Q27106287
FT-0624277
CYCLOPHOSPHAMIDE [WHO-IP]
8N3DW7272P
Cyclophosphamide, United States Pharmacopeia (USP) Reference Standard

MDL Number

MFCD00149395

Customs Code

2924299090

FAQ

What is Cyclophosphamide hydrate (CAS: 6055-19-2)?

Cyclophosphamide hydrate (CAS: 6055-19-2) is a white crystalline powder with the chemical formula C2H2Cl2N2O2P·H2O. It is hygroscopic, soluble in water, and has a molecular weight of approximately 263.19 g/mol. This compound is primarily known as an antineoplastic agent, used in cancer treatment and immunosuppression.

What are the main uses of Cyclophosphamide hydrate (CAS: 6055-19-2)?

Cyclophosphamide hydrate (CAS: 6055-19-2) is mainly used in pharmaceuticals as a chemotherapy drug for cancers like lymphoma, leukemia, and certain solid tumors. It also serves as an immunosuppressive agent in organ transplantation and autoimmune disorders. Additionally, it finds applications in veterinary medicine and research for its alkylating properties.

Is Cyclophosphamide hydrate (CAS: 6055-19-2) safe?

Cyclophosphamide hydrate (CAS: 6055-19-2) is a hazardous substance and requires strict safety measures. It may cause bone marrow suppression, infertility, and other side effects, necessitating protective equipment during handling. Safety standards include adherence to OSHA guidelines and proper disposal to minimize health and environmental risks.

How should Cyclophosphamide hydrate (CAS: 6055-19-2) be stored?

Cyclophosphamide hydrate (CAS: 6055-19-2) should be stored in a cool, dry place (2-8°C) away from light and moisture. Keep in airtight, labeled containers to maintain stability and prevent degradation. Avoid freezing and ensure storage conditions comply with pharmaceutical guidelines to preserve efficacy.