Acetazolamide EP Impurity A

Basic Information

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CAS Number

60320-32-3

Molecular Formula

C4H4ClN3OS

Molecular Weight

177.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Boiling Point

°Cat760mmHg

Density

1.608

Refractive Index

1.644

SMILES

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CC(=O)Nc1nnc(Cl)s1

InChI

InChI=1S/C4H4ClN3OS/c1-2(9)6-4-8-7-3(5)10-4/h1H3,(H,6,8,9)

InChIKey

CKUUONNLVFAZNC-UHFFFAOYSA-N

LogP

1.1498999999999997

Topological Polar Surface Area

54.88 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

145

Synonyms & References

English

Acetamide,N-(5-chloro-1,3,4-thiadiazol-2-yl)-
N-(5-Chloro-1,3,4-thiadiazol-2-yl)acetamide
NSC 231656
N-(5-chloro-1,3,4-thiadiazol-2-yl)acetamide

MDL Number

MFCD00723607

FAQ

What are the physical and chemical properties of Acetazolamide EP Impurity A (CAS: 60320-32-3)?

Acetazolamide EP Impurity A (CAS: 60320-32-3) is a white crystalline powder with a molecular weight of approximately 238.26 g/mol. It is slightly soluble in water and ethanol. Chemically, it is less reactive compared to the main compound, with limited reactivity towards common acids and bases. It has a melting point around 150-160°C and is stable under normal storage conditions.

How is Acetazolamide EP Impurity A (CAS: 60320-32-3) typically synthesized?

Acetazolamide EP Impurity A (CAS: 60320-32-3) is synthesized through a multi-step process involving the condensation of acetylacetone and ethyl 2-thiouracil. The reaction is typically catalyzed by anhydrous zinc chloride. The product is isolated by recrystallization from water, yielding a crystalline product with high purity.

What industries use Acetazolamide EP Impurity A (CAS: 60320-32-3)?

Acetazolamide EP Impurity A (CAS: 60320-32-3) is primarily used in the pharmaceutical industry as a by-product in the synthesis of acetazolamide, a carbonic anhydrase inhibitor used in the treatment of glaucoma and altitude sickness. It is also of interest in analytical chemistry for quality control purposes.

What precautions should be taken when handling Acetazolamide EP Impurity A (CAS: 60320-32-3)?

When handling Acetazolamide EP Impurity A (CAS: 60320-32-3), proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation. Spills should be cleaned up immediately using appropriate absorbents. For detailed safety information, refer to the Safety Data Sheet (SDS).