Acetazolamide EP Impurity A(CAS: 60320-32-3)

Acetazolamide EP Impurity A (CAS: 60320-32-3) is a white crystalline powder with a molecular weight of approximately 238.26 g/mol. It is slightly soluble in water and ethanol. Chemically, it is less reactive compared to the main compound, with limited reactivity towards common acids and bases. It has a melting point around 150-160°C and is stable under normal storage conditions.

Acetazolamide EP Impurity A (CAS: 60320-32-3) is synthesized through a multi-step process involving the condensation of acetylacetone and ethyl 2-thiouracil. The reaction is typically catalyzed by anhydrous zinc chloride. The product is isolated by recrystallization from water, yielding a crystalline product with high purity.

Acetazolamide EP Impurity A (CAS: 60320-32-3) is primarily used in the pharmaceutical industry as a by-product in the synthesis of acetazolamide, a carbonic anhydrase inhibitor used in the treatment of glaucoma and altitude sickness. It is also of interest in analytical chemistry for quality control purposes.

When handling Acetazolamide EP Impurity A (CAS: 60320-32-3), proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation. Spills should be cleaned up immediately using appropriate absorbents. For detailed safety information, refer to the Safety Data Sheet (SDS).