Tetrabenazine

Basic Information

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CAS Number

58-46-8

Molecular Formula

C19H27NO3

Molecular Weight

317.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

124.0 to 130.0 deg-C

Boiling Point

456.71°C (rough estimate)

Flash Point

225.3°C

Solubility

DMSO: >10mg/mL

Refractive Index

1.5180 (estimate)

Vapor Pressure

0.0±1.1 mmHg at 25°C

SMILES

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CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC

InChI

InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3

InChIKey

MKJIEFSOBYUXJB-UHFFFAOYSA-N

LogP

log Kow = 2.66 (est)

Topological Polar Surface Area

38.77 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

425

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1(b) Class 6.1(b)

Synonyms & References

English

BT164463
NSC172187
Tetrabenazin
TETRABENAZINE
2H-Benzo(a)quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-(9CI)
9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one
HMS2966E06
AS-35785
1,2,4,6,7,11b-Hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one
FT-0700948
2-oxo-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizine
2-Oxo-3-isobutyl-9,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine
A917912
3-isobutyl-9-,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one
BDBM50017701
1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-Benzo[a]quinolizin-2-one
GTPL4834
SB49797
2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-
FT-0772314
Ro 1-9569 Racemate
FT-0674921
FT-0771873
3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one #
Deutetrabenazine
Nitoman, Xenazine, Tetrabenazine
Tetrabenazine [INN:BAN]
HMS3430F03
(-)-tetrabenazine
Tetrabenazine (Nitoman, Xenazine)
Tetrabenazinum [INN-Latin]

MDL Number

MFCD00042740

Customs Code

2933990090

FAQ

What is Tetrabenazine (CAS: 58-46-8)?

Tetrabenazine (CAS: 58-46-8) is a substituted tetrahydroisoquinoline derivative, primarily used in the treatment of chorea associated with Huntington's disease. It is also studied for its effects on other movement disorders and psychiatric conditions.

What are the main uses of Tetrabenazine (CAS: 58-46-8)?

Tetrabenazine (CAS: 58-46-8) is mainly used for the treatment of chorea associated with Huntington's disease. It is also studied for its potential in managing other movement disorders and psychiatric conditions.

Is Tetrabenazine (CAS: 58-46-8) safe?

Tetrabenazine (CAS: 58-46-8) is generally considered safe when used under medical supervision. However, it can cause side effects such as depression, suicidal thoughts, and extrapyramidal symptoms. Patients should be monitored closely, and the drug should be used with caution, especially in individuals with a history of psychiatric disorders.

How should Tetrabenazine (CAS: 58-46-8) be stored?

Tetrabenazine (CAS: 58-46-8) should be stored at room temperature, between 15-30°C (59-86°F), in a tightly sealed container, protected from light. It should be kept out of reach of children and away from moisture and heat to maintain its stability and efficacy.