Methyl 6-(hydroxymethyl)nicotinate

Basic Information

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CAS Number

56026-36-9

Molecular Formula

C8H9NO3

Molecular Weight

167.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

75.0 to 79.0 deg-C

Boiling Point

293.4±30.0 °C at 760 mmHg

Density

1.244

Flash Point

131.3℃

Refractive Index

1.546

SMILES

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COC(=O)C1=CN=C(C=C1)CO

InChI

InChI=1S/C8H9NO3/c1-12-8(11)6-2-3-7(5-10)9-4-6/h2-4,10H,5H2,1H3

InChIKey

QVLONHSXRWCCAE-UHFFFAOYSA-N

LogP

0.3605

Topological Polar Surface Area

59.42 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

160

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AB00076052-01
methyl 6-hydroxymethylnicotinate
6-(Hydroxymethyl)pyridine-3-carboxylate Methyl Ester
56026-36-9
SCHEMBL204895
SY007641
Oprea1_479622
CBDivE_012360
5W-0644
methyl 6-(hydroxymethyl)nicotinate
Z1139751257
3-Pyridinecarboxylicacid, 6-(hydroxymethyl)-, methyl ester
MFCD00643821
J-522516
HMS1683H02
FT-0648897
6-Hydroxymethyl-nicotinic acid methyl ester, AldrichCPR
QVLONHSXRWCCAE-UHFFFAOYSA-N
AKOS000512710
DTXSID00355022
CS-W002650
3-Pyridinecarboxylic acid, 6-(hydroxymethyl)-, methyl ester
A8072
methyl 6-hydroxymethyl-nicotinate
AC-23249
6-Hydroxymethylnicotinic acid methyl ester
methyl6-(hydroxymethyl)nicotinate
M2750
CL0242
methyl 6-(hydroxymethyl)pyridine-3-carboxylate
BCP26466

MDL Number

MFCD00643821

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Methyl 6-(hydroxymethyl)nicotinate (CAS: 56026-36-9)?

Methyl 6-(hydroxymethyl)nicotinate (CAS: 56026-36-9) is a white crystalline solid with a molecular weight of approximately 181.23 g/mol. It is slightly soluble in water and readily soluble in organic solvents. Chemically, it is prone to hydrolysis and can react with bases and reducing agents.

How is Methyl 6-(hydroxymethyl)nicotinate (CAS: 56026-36-9) typically synthesized?

Methyl 6-(hydroxymethyl)nicotinate (CAS: 56026-36-9) is synthesized by the reaction of 6-(hydroxymethyl)nicotinic acid with methylamine in the presence of a suitable catalyst such as p-toluenesulfonic acid. The process yields high purity product with excellent selectivity and yield.

What industries use Methyl 6-(hydroxymethyl)nicotinate (CAS: 56026-36-9)?

Methyl 6-(hydroxymethyl)nicotinate (CAS: 56026-36-9) is primarily used in the pharmaceutical industry for drug synthesis, as well as in the chemical industry for polymer and sensor applications. It is also utilized in research for its reactivity and functional groups.

What precautions should be taken when handling Methyl 6-(hydroxymethyl)nicotinate (CAS: 56026-36-9)?

When handling Methyl 6-(hydroxymethyl)nicotinate (CAS: 56026-36-9), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation. Spills should be immediately cleaned up, and the material safety data sheet (MSDS) should be consulted for detailed handling instructions and emergency procedures.