4-Chloro-1-methylpiperidine

Basic Information

View in Editor

CAS Number

5570-77-4

Molecular Formula

C6H12ClN

Molecular Weight

133.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

160-165 ºC

Boiling Point

162°C

Flash Point

48 °C

Refractive Index

1.4670-1.4710

SMILES

View in Editor

CN1CCC(CC1)Cl

InChI

InChI=1S/C6H12ClN/c1-8-4-2-6(7)3-5-8/h6H,2-5H2,1H3

InChIKey

MYGXGCCFTPKWIH-UHFFFAOYSA-N

LogP

1.3194

Topological Polar Surface Area

3.24 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

66.9

Safety Information

View Safety Information

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 3 (8) Class 3 (8)

Synonyms & References

English

AKOS005216211
UNII-3J2YSE7ZGE
AC-6961
4-Chloro-1-methylpiperidine, AldrichCPR
W-105550
C2465
2-AMINO-5-NITRONICOTINICACID,
1-METHYL-4-PIPERIDYL CHLORIDE
SCHEMBL364269
4-Chloro-1-methylpiperidine
4-chloro-1-methyl piperidine
Piperidine, 4-chloro-1-methyl-
A830767
1-Methyl-4-chloro-piperidine
CS-W013387
MFCD00044489
1-Methyl-4-chloropiperidine hydrochloride (Salt/Mix)
N-Methyl-4-Chloropiperdine
EN300-206602
SR-01000944775-1
N-methyl 4-chloropiperidine
N-methyl-4-chloropiperidine
AB01976
BCP05291
4-Chloro-N-methylpiperidine
3J2YSE7ZGE
NS00033372
EINECS 226-942-4
1-Methyl-4-chloropiperidine
FT-0617982
4-Chloro-N-methylpiperidine hydrochloride (Salt/Mix)

MDL Number

MFCD00044489

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-Chloro-1-methylpiperidine (CAS: 5570-77-4)?

4-Chloro-1-methylpiperidine (CAS: 5570-77-4) is a colorless oily liquid with a molecular weight of approximately 132.57 g/mol. It has a boiling point of 132-133°C and a solubility of about 0.1 g/100 mL in water. The compound is moderately reactive, particularly towards nucleophiles and bases. It is used in various chemical syntheses and pharmaceutical applications due to its structural properties.

How is 4-Chloro-1-methylpiperidine (CAS: 5570-77-4) typically synthesized?

4-Chloro-1-methylpiperidine (CAS: 5570-77-4) is typically synthesized through the reaction of 1-methylpiperidine with hydrochloric acid. This process involves the nucleophilic substitution of the amine nitrogen with chlorine. Commonly, this reaction is carried out in an organic solvent under reflux conditions. The yield of the product can vary, but under optimal conditions, it can be as high as 85%. The use of a suitable catalyst may improve the reaction selectivity and yield.

What industries use 4-Chloro-1-methylpiperidine (CAS: 5570-77-4)?

4-Chloro-1-methylpiperidine (CAS: 5570-77-4) is utilized in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of medicinal compounds. It is also used in the production of certain polymers and as a reagent in organic synthesis. Its applications extend to sensor technology and semiconductor manufacturing, where its unique chemical properties make it valuable.

What precautions should be taken when handling 4-Chloro-1-methylpiperidine (CAS: 5570-77-4)?

When handling 4-Chloro-1-methylpiperidine (CAS: 5570-77-4), it is essential to follow strict safety protocols. Always use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. In case of a spill, immediately contain the spill and clean it up according to the safety data sheet (SDS). Always consult the SDS for specific handling and disposal guidelines.