1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol

Basic Information

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CAS Number

5423-67-6

Molecular Formula

C13H13NO

Molecular Weight

199.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

424.3°C at 760 mmHg

SMILES

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C1C(CNC2=C1C=CC3=CC=CC=C32)O

InChI

InChI=1S/C13H13NO/c15-11-7-10-6-5-9-3-1-2-4-12(9)13(10)14-8-11/h1-6,11,14-15H,7-8H2

InChIKey

WKJMQLMWPMZUQH-UHFFFAOYSA-N

LogP

2.1687

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

231

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Z56943435
1,2,3,4-Tetrahydrobenzo(h)quinolin-3-ol
WLZ3350
AKOS001042097
MFCD00507345
Benzo[h]quinolin-3-ol,2,3,4-tetrahydro-
DTXSID401252939
NSC13233
HMS1748I11
AKOS016050411
W-105652
DS-3880
CS-0015222
1,2,3,4-Tetrahydro-benzohquinolin-3-ol
1,2,3,4-tetrahydrobenzo-h-quinolin-3-ol
SMR001301101
AC-29268
5423-67-6
NSC 13233
A830057
1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol #
SY066553
HMS3086J19
NSC-13233
EINECS 226-556-6
EN300-06275
MLS002638308
CHEMBL1868082
Benzo[h]quinolin-3-ol, 1,2,3,4-tetrahydro-
3-hydroxy-1,2,3,4-tetrahydrobenzo[h]quinoline
AMY23152

MDL Number

MFCD00507345

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol (CAS: 5423-67-6)?

1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol is a white crystalline solid with a molecular weight of approximately 225.24 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol and acetone. Chemically, it is less reactive compared to its parent compound, benzo[h]quinolin-3-ol, with moderate reactivity towards acidic and basic conditions. It has a melting point of about 168-170°C and a boiling point of around 280-285°C under reduced pressure.

How is 1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol (CAS: 5423-67-6) typically synthesized?

1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol can be synthesized via the reduction of benzo[h]quinolin-3-one using a hydrogenation process in the presence of a catalyst like palladium on carbon. Typically, this involves dissolving the quinone in a suitable solvent, adding a hydrogenation catalyst, and hydrogenating under conditions of pressure and temperature until the desired reduction product is achieved, with high selectivity and good yield.

What industries use 1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol (CAS: 5423-67-6)?

1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol is utilized in the pharmaceutical industry for its potential as a precursor in the synthesis of certain medicinal agents. It also finds application in the polymer industry for the development of novel materials, and in the field of sensors and semiconductors for its electronic properties.

What precautions should be taken when handling 1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol (CAS: 5423-67-6)?

When handling 1,2,3,4-Tetrahydrobenzo[h]quinolin-3-ol, it is advisable to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up carefully using appropriate materials, and the area should be thoroughly washed down with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal guidelines.